Aromatase inhibitors: A new approach for controlling ovarian function in cattle

MJ Yapura, EM Zwiefelhofer, RA Pierson, GP Adams - Theriogenology, 2018 - Elsevier
Numerous treatments and protocols have been used to control the reproductive cycle in
cattle, with varying effectiveness and many involving the administration of steroid hormones …

The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes

MB Kivrak, O Corum, H Alkan, O Atik, I Aydin, K Uney - Theriogenology, 2021 - Elsevier
The aim of this study was to determine the pharmacokinetics of letrozole and its effect on
FSH and LH concentrations after single (IV, IM, SC) and repeated IV doses in anestrous …

[HTML][HTML] Timed artificial insemination protocols inádairy cattle: Functioning, shortcomings, and improvements

A Boudaoud - Czech Journal of Animal Science, 2023 - cjas.agriculturejournals.cz
Oestrus detection is currently atáthe top ofáthe factors limiting the success ofáartificial
insemination inádairy herds. This limitation becomes more pronounced asámilk production …

Testicular estradiol and the pattern of Sertoli cell proliferation in prepuberal bulls

T Berger - Theriogenology, 2019 - Elsevier
Sertoli cells nourish developing sperm with the number of Sertoli cells being a major
determinant of sperm production capacity in a male. The objectives of these studies were to …

Pharmacokinetics of letrozole and effects of its increasing doses on gonadotropins in ewes during the breeding season

MB Kivrak, O Corum, M Yuksel, E Turk… - Journal of Veterinary …, 2024 - Wiley Online Library
Letrozole is a non‐steroidal, third‐generation aromatase inhibitor used in humans. Although
letrozole is not approved for use in animals, it is used off‐label in cases of synchronization …

Effect of vehicle and route of administration of letrozole on ovarian function in a bovine model

MJ Yapura, RJ Mapletoft, RA Pierson… - Reproduction …, 2014 - CSIRO Publishing
The objective of this study was to determine the effects of vehicle and route of administration
of letrozole on ovarian function in sexually mature beef heifers. On Day 3 (Day 0= ovulation) …

Effect of a non-steroidal aromatase inhibitor on ovarian function and synchronicity of estrus in ewes at subtropics

AD MA - Journal of Applied Veterinary Sciences, 2020 - journals.ekb.eg
Effects of non-steroidal aromatase inhibitor letrozole on ovarian function in ewe were
investigated through testing the hypothesis that letrozole will arrest the growth of dominant …

Synchronization of ovulation in cattle with an aromatase inhibitor–based protocol

MJ Yapura, RJ Mapletoft, RA Pierson, J Singh… - Theriogenology, 2016 - Elsevier
A study was designed to determine the effect of stage of the estrous cycle on the proportion
of animals that ovulated and the synchrony of ovulation of heifers treated with an aromatase …

An attempt to potentiate the ovarian superstimulatory response in cattle by co-treatment with an aromatase inhibitor

EM Zwiefelhofer, RJ Mapletoft, GP Adams - Theriogenology, 2020 - Elsevier
Letrozole is used for the treatment of subfertility in women undergoing ovarian
superstimulation, but the mechanism of action has not been investigated critically. The …

Aromatase inhibitor treatment with an intravaginal device and its effect on pre-ovulatory ovarian follicles in a bovine model

J Yapura, RJ Mapletoft, RA Pierson, J Singh… - Reproductive Biology …, 2013 - Springer
Background Letrozole, a non-steroidal aromatase inhibitor, prevents the body from
producing its own estrogen. The objectives of the present study were to test the hypotheses …