Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …

Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Physical exercise is generally beneficial to all aspects of human and animal health, slowing
cognitive ageing and neurodegeneration. The cognitive benefits of physical exercise are …

The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …

Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a
disorder characterized by synapse and memory failure. Irisin is an exercise-induced …

Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Physical activity is one of the modifiable factors of cognitive decline and dementia with the
strongest evidence. Although many influential reviews have illustrated the neurobiological …