Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Antithrombin is a key endogenous anticoagulant whose deficiency constitutes a strong risk
factor for thrombosis. The study of antithrombin deficiency has generated excellent, and in …

Antithrombin is a key inhibitor of the coagulation cascade, but it may also function as an anti-
inflammatory, anti-angiogenic, anti-viral and anti-apoptotic protein. Here, we report a novel …

Essentials• Antithrombin Budapest3 (ATBp3; p. Leu131Phe) causing heparin‐binding‐site
defect is common.• We studied the clinical and laboratory phenotype of a large Hungarian …

Carbohydrates fulfil many common as well as extremely important functions in nature. They
show a variety of molecular displays–eg, free mono-, oligo-, and polysaccharides …

Pediatric thromboembolism (≤ 18 years) is very rare (0.07-0.14/10,000/year) but may be
more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin …

Background Hereditary antithrombin (AT) deficiency is a rare autosomal dominant disorder
characterised by decreased AT activity in plasma and predisposition to recurrent venous …

Antithrombin (AT) is a serine protease inhibitor, its activity is highly accelerated by heparin.
Mutations at the heparin-binding region lead to functional defect, type II heparin-binding site …

Introduction Inherited antithrombin (AT) deficiency is a heterogeneous disease. Due to low
prevalence, only a few studies are available concerning genotype-phenotype associations …

Atresia of inferior vena cava (IVC) is a rare congenital malformation associated with high risk
of venous thrombosis that still has unknown etiology, although intrauterine IVC thrombosis …