Abstract Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal
antibodies with precise targeting and payloads with efficient killing, show great clinical …

Covering: 2012 to 2021 Cyclopropane attracts wide interests in the fields of synthetic and
pharmaceutical chemistry, and chemical biology because of its unique structural and …

INTRODUCTION Members of the human gut microbiota have been implicated in the
development and progression of colorectal cancer (CRC). These CRC-associated …

Antibody–drug conjugates (ADCs) that are currently on the market or in clinical trials are
predominantly based on two drug classes: auristatins and maytansinoids. Both are tubulin …

Breast cancer is a heterogeneous group of malignancies with a spectrum of molecular
subtypes, pathologies and outcomes that together comprise the most common non …

Highlights•High ALDH expression in CSCs is associated with a worse prognosis.•ALDH
isozyme expression can to some extent be cancer specific.•Rational approach to chemical …

Synthetic analogues of the DNA-alkylating cytotoxins of the duocarmycin class have been
extensively investigated in the past 40 years, driven by their high potency, their unusual …

Despite significant advances in treatment strategies over the past decade, selective
treatment of breast cancer with limited side-effects still remains a great challenge. The …

Certain commensal and pathogenic bacteria produce colibactin, a small-molecule genotoxin
that causes interstrand cross-links in host cell DNA. Although colibactin alkylates DNA, the …

The treatment of cancer with common anti-proliferative agents generally suffers from an
insufficient differentiation between normal and malignant cells which results in extensive …