Structural basis of protein kinase C isoform function
SF Steinberg - Physiological reviews, 2008 - journals.physiology.org
Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …
Preconditioning the myocardium: from cellular physiology to clinical cardiology
Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …
Cytoplasmic signaling pathways that regulate cardiac hypertrophy
JD Molkentin, GW Dorn II - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract This review discusses the rapidly progressing field of cardiomyocyte signal
transduction and the regulation of the hypertrophic response. When stimulated by a wide …
transduction and the regulation of the hypertrophic response. When stimulated by a wide …
Regulation of protein kinase C
AC Newton - Current opinion in cell biology, 1997 - Elsevier
Protein kinase C has been in the spotlight since the discovery two decades ago that is
activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring …
activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring …
Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC
L Chen, H Hahn, G Wu, CH Chen… - Proceedings of the …, 2001 - National Acad Sciences
Conflicting roles for protein kinase C (PKC) isozymes in cardiac disease have been
reported. Here, δPKC-selective activator and inhibitor peptides were designed rationally …
reported. Here, δPKC-selective activator and inhibitor peptides were designed rationally …
[HTML][HTML] The physiological role of cardiac cytoskeleton and its alterations in heart failure
V Sequeira, LLAM Nijenkamp, JA Regan… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …
generation of force and movement central to the work generated by the heart. During each …
Protein kinase Cθ in T cell activation
The novel protein kinase C (PKC) isoform, PKCθ, is selectively expressed in T lymphocytes
and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells …
and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells …
Ischemic Preconditioning: From Adenosine Receptor to KATP Channel
MV Cohen, CP Baines… - Annual review of …, 2000 - annualreviews.org
▪ Abstract Ischemic preconditioning is a phenomenon whereby exposure of the myocardium
to a brief episode of ischemia and reperfusion markedly reduces tissue necrosis induced by …
to a brief episode of ischemia and reperfusion markedly reduces tissue necrosis induced by …
[HTML][HTML] Specific involvement of PKC-ε in sensitization of the neuronal response to painful heat
P Cesare, LV Dekker, A Sardini, PJ Parker… - Neuron, 1999 - cell.com
Pain is unique among sensations in that the perceived intensity increases, or sensitizes,
during exposure to a strong stimulus. One important mediator of sensitization is bradykinin …
during exposure to a strong stimulus. One important mediator of sensitization is bradykinin …
A novel nociceptor signaling pathway revealed in protein kinase C ε mutant mice
SG Khasar, YH Lin, A Martin, J Dadgar, T McMahon… - Neuron, 1999 - cell.com
There is great interest in discovering new targets for pain therapy since current methods of
analgesia are often only partially successful. Although protein kinase C (PKC) enhances …
analgesia are often only partially successful. Although protein kinase C (PKC) enhances …