Genome-based prediction of bacterial antibiotic resistance
Clinical microbiology has long relied on growing bacteria in culture to determine
antimicrobial susceptibility profiles, but the use of whole-genome sequencing for antibiotic …
antimicrobial susceptibility profiles, but the use of whole-genome sequencing for antibiotic …
Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis
E Balsells, L Guillot, H Nair, MH Kyaw - PloS one, 2017 - journals.plos.org
Background Routine immunisation with pneumococcal conjugate vaccines (PCV7/10/13)
has reduced invasive pneumococcal disease (IPD) due to vaccine serotypes significantly …
has reduced invasive pneumococcal disease (IPD) due to vaccine serotypes significantly …
Pivotal phase 3 randomized clinical trial of the safety, tolerability, and immunogenicity of 20-valent pneumococcal conjugate vaccine in adults aged≥ 18 years
B Essink, C Sabharwal, K Cannon… - Clinical infectious …, 2022 - academic.oup.com
Abstract Background Pneumococcal conjugate vaccines (PCVs) have significantly reduced
pneumococcal disease, but disease from non-PCV serotypes remains. The safety …
pneumococcal disease, but disease from non-PCV serotypes remains. The safety …
Safety, tolerability, and immunogenicity of a 20-valent pneumococcal conjugate vaccine (PCV20) in adults 60 to 64 years of age
D Hurley, C Griffin, M Young Jr, DA Scott… - Clinical Infectious …, 2021 - academic.oup.com
Abstract Background Pneumococcal conjugate vaccines (PCVs) have significantly
decreased pneumococcal disease worldwide; however, expanding serotype coverage may …
decreased pneumococcal disease worldwide; however, expanding serotype coverage may …
Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an …
Background Invasive pneumococcal disease remains an important health priority owing to
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …
Biological and epidemiological features of antibiotic-resistant Streptococcus pneumoniae in pre-and post-conjugate vaccine eras: a United States perspective
L Kim, L McGee, S Tomczyk, B Beall - Clinical microbiology …, 2016 - Am Soc Microbiol
Streptococcus pneumoniae inflicts a huge disease burden as the leading cause of
community-acquired pneumonia and meningitis. Soon after mainstream antibiotic usage …
community-acquired pneumonia and meningitis. Soon after mainstream antibiotic usage …
Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection
Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million
deaths annually, especially in young children and the elderly. To date, at least 98 different …
deaths annually, especially in young children and the elderly. To date, at least 98 different …
Exploring bacterial diversity via a curated and searchable snapshot of archived DNA sequences
The open sharing of genomic data provides an incredibly rich resource for the study of
bacterial evolution and function and even anthropogenic activities such as the widespread …
bacterial evolution and function and even anthropogenic activities such as the widespread …
International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact
Background Pneumococcal conjugate vaccines have reduced the incidence of invasive
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …
Pneumococcal within-host diversity during colonization, transmission and treatment
Characterizing the genetic diversity of pathogens within the host promises to greatly improve
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …