[HTML][HTML] Deciphering bacterial epigenomes using modern sequencing technologies
J Beaulaurier, EE Schadt, G Fang - Nature Reviews Genetics, 2019 - nature.com
Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …
Epigenetic modification of nucleic acids: from basic studies to medical applications
The epigenetic modification of nucleic acids represents one of the most significant areas of
study in the field of nucleic acids because it makes gene regulation more complex and …
study in the field of nucleic acids because it makes gene regulation more complex and …
Single-base mapping of m6A by an antibody-independent method
N 6-methyladenosine (m6A) is one of the most abundant messenger RNA modifications in
eukaryotes involved in various pivotal processes of RNA metabolism. The most popular high …
eukaryotes involved in various pivotal processes of RNA metabolism. The most popular high …
[HTML][HTML] Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
DNA base modifications, such as C5-methylcytosine (5mC) and N6-methyldeoxyadenosine
(6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and …
(6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and …
Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution
The discovery of N6-methyldeoxyadenine (6mA) across eukaryotes led to a search for
additional epigenetic mechanisms. However, some studies have highlighted confounding …
additional epigenetic mechanisms. However, some studies have highlighted confounding …
Deep transformers and convolutional neural network in identifying DNA N6-methyladenine sites in cross-species genomes
As one of the most common post-transcriptional epigenetic modifications, N6-methyladenine
(6 mA), plays an essential role in various cellular processes and disease pathogenesis …
(6 mA), plays an essential role in various cellular processes and disease pathogenesis …
Meta-i6mA: an interspecies predictor for identifying DNA N6-methyladenine sites of plant genomes by exploiting informative features in an integrative machine …
Abstract DNA N 6-methyladenine (6mA) represents important epigenetic modifications,
which are responsible for various cellular processes. The accurate identification of 6mA sites …
which are responsible for various cellular processes. The accurate identification of 6mA sites …
[HTML][HTML] DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress
Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-
hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine …
hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine …
[HTML][HTML] SDM6A: a web-based integrative machine-learning framework for predicting 6mA sites in the rice genome
DNA N 6-adenine methylation (6mA) is an epigenetic modification in prokaryotes and
eukaryotes. Identifying 6mA sites in rice genome is important in rice epigenetics and …
eukaryotes. Identifying 6mA sites in rice genome is important in rice epigenetics and …
Navigating the pitfalls of mapping DNA and RNA modifications
Y Kong, EA Mead, G Fang - Nature Reviews Genetics, 2023 - nature.com
Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …
important regulatory information. Reliable high-resolution mapping of these modifications is …