Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …

Alveoli, the lung's respiratory units, are tiny sacs where oxygen enters the bloodstream. They
are lined by flat alveolar type 1 (AT1) cells, which mediate gas exchange, and AT2 cells …

BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …

Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …

Blood vessels define local microenvironments in the skeletal system, play crucial roles in
osteogenesis and provide niches for haematopoietic stem cells,,,,,. The properties of niche …

Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …