Abstract Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation
vaccine against smallpox and serves as a potent vector system for development of new …

The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9
(Cas9) technology is revolutionizing genome editing approaches. Its high efficiency …

Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that affects humans and can
cause severe neurological complications, including Guillain-Barré syndrome and …

South Africa is endemic for lumpy skin disease and is therefore reliant on various live
attenuated vaccines for the control and prevention of the disease. In recent years …

Attenuated vaccine strains of lumpy skin disease virus (LSDV) have become increasingly
popular as recombinant vaccine vectors, to target both LSDV, as well as other pathogens …

Modified vaccinia virus Ankara (MVA) is a replication-deficient poxvirus, attenuated in chick
embryo fibroblast primary cells. It has been utilised as a viral vector to develop many …

Despite the effectiveness of classic treatments and available diagnostic tools, cancer
continues to be a leading world health problem, with devastating cancer-related death rates …

Introduction Immunotherapy is a rapidly evolving area of cancer therapeutics aimed at
driving a systemic immune response to fight cancer. Oncolytic viruses (OVs) are at the …

Recombinant adeno-associated viral (rAAV) vectors have been widely used in human gene
therapy. One major impediment to its broad application is the inability to produce high …

Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary
applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and …