Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

This guideline provides recommendations for clinicians providing pain care, including those
prescribing opioids, for outpatients aged≥ 18 years. It updates the CDC Guideline for …

Opioids were one of the earliest classes of medications used for pain across a variety of
conditions, but morbidity and mortality have been increasingly associated with their chronic …

We attribute the recent quadrupling of heroin death rates to the August 2010 reformulation of
an oft-abused prescription opioid, OxyContin. The new abuse-deterrent formulation led …

We investigated prescribing patterns for four opioid use disorder (OUD) medications: 1)
injectable naltrexone, 2) oral naltrexone, 3) sublingual or oralmucosal buprenorphine …

Objective Prescription opioid use and deaths related to serious toxicity, including overdose,
have increased dramatically in the United States since 1999. However, factors associated …

Objective Opioid use disorder (OUD), which includes the morbidity of dependence and
mortality of overdose, has reached epidemic proportions in the United States …

Abstract Background and Aims The burden of premature mortality due to opioid‐related
death has not been fully characterized. We calculated temporal trends in the proportion of …

Background and aims The full burden of the opioid epidemic on US hospitals has not been
described. We aimed to estimate how heroin (HOD) and prescription opioid (POD) overdose …

Aggressive pain treatment was advocated for ESRD patients, but new Centers for Disease
Control and Prevention guidelines recommend cautious opioid prescription. Little is known …