Fibroblast growth factors (FGFs) act as key signalling molecules in brain development,
maintenance, and repair. They influence the intricate relationship between myelinating cells …

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system (CNS) affecting more than two million people worldwide. In MS …

Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic
nerve (ON) severely affects vision. Understanding the molecular mechanism of …

Multiple sclerosis is an autoimmune neurodegenerative disorder resulting in motor
dysfunction and cognitive decline. The inflammatory and neurodegenerative changes seen …

Multiple sclerosis (MS) is an inflammatory immune-mediate disorder of the central nervous
system (CNS), primarily affecting the myelin sheath and followed by neurodegeneration …

The role of the fibroblast growth factor (FGF) system in brain-related disorders has received
considerable attention in recent years. To understand the role of this system in neurological …

Neuroplasticity is essential to prevent clinical worsening despite continuing neuronal loss in
several brain diseases, including multiple sclerosis (MS). The precise nature of the …

Small molecules as useful chemical tools can affect cell differentiation and even change cell
fate. It is demonstrated that LY294002, a small molecule inhibitor of phosphatidylinositol 3 …

Recent findings showing that epidermal growth factor (EGF) is significantly decreased in the
cerebrospinal fluid (CSF) and spinal cord (SC) of living or deceased multiple sclerosis (MS) …

A variety of growth factors are being explored as therapeutic agents relevant to the axonal
and oligodendroglial deficits that occur as a result of demyelinating lesions such as are …