Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics

Y Ding, JP Ting, J Liu, S Al-Azzam, P Pandya, S Afshar - Amino Acids, 2020 - Springer
With the development of modern chemistry and biology, non-proteinogenic amino acids
(NPAAs) have become a powerful tool for developing peptide-based drug candidates. Drug …

Anti-amyloid nanoclusters for the treatment of brain hazards associated with incurable neurodegenerative diseases

D Li, Z Wang, B Kumari, X Mei, ZY Wang - Materials Today Chemistry, 2023 - Elsevier
Neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease
(AD) have no cure and pose a serious threat to human health. The accumulated amyloid has …

Naphthalene monoimide derivative ameliorates amyloid burden and cognitive decline in a transgenic mouse model of alzheimer's disease

S Samanta, K Rajasekhar, M Ramesh… - Advanced …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is a major neurodegenerative disorder and the leading cause of
dementia worldwide. Predominantly, misfolding and aggregation of amyloid‐β (Aβ) peptides …

Solvent relaxation NMR: a tool for real-time monitoring water dynamics in protein aggregation landscape

I Chakraborty, RK Kar, D Sarkar, S Kumar… - ACS Chemical …, 2021 - ACS Publications
Solvent dynamics strongly induce the fibrillation of an amyloidogenic system. Probing the
solvation mechanism is crucial as it enables us to predict different proteins' functionalities …

Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone–Dopamine hybrid

A Paul, GKK Viswanathan, A Huber, E Arad… - The FEBS …, 2021 - Wiley Online Library
Misfolding and aggregation of tau protein, into pathological amyloids, are hallmarks of a
group of neurodegenerative diseases collectively termed tauopathies and their modulation …

Electrolyte-Gated Organic Field-Effect Transistor for Monitoring Amyloid Aggregation

S Ruiz-Molina, C Martinez-Domingo… - ACS Applied …, 2024 - ACS Publications
Amyloid-β peptide aggregation is a crucial process in neurological disorders such as
Alzheimer's and Parkinson's diseases. Amyloids tend to assemble first into oligomers and …

Peptide-based amyloid-beta aggregation inhibitors

N Sehra, R Parmar, R Jain - RSC Medicinal Chemistry, 2025 - pubs.rsc.org
Aberrant protein misfolding and accumulation is considered to be a major pathological pillar
of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases …

An explicitly designed paratope of amyloid-β prevents neuronal apoptosis in vitro and hippocampal damage in rat brain

A Paul, S Kumar, S Kalita, S Kalita, D Sarkar… - Chemical …, 2021 - pubs.rsc.org
Synthetic antibodies hold great promise in combating diseases, diagnosis, and a wide range
of biomedical applications. However, designing a therapeutically amenable, synthetic …

Empowering Antimicrobial Peptides: Harnessing Nanotechnology and Engineering Strategies to Combat Microbial Resistance

D Avinash, A Bisht, M Kumar, S Thakur, P Patel… - Peptide …, 2024 - Wiley Online Library
Antimicrobial peptides (AMPs) are being studied for their potential in addressing microbial
resistance, a significant issue in treating infections. More than 22,500 AMPs are listed in the …

Crystal structure and supramolecular arrangement of heterochiral tripeptides

G Dolai, RS Giri, S Roy, B Mandal - Peptide Science, 2021 - Wiley Online Library
The self‐assembly properties of all possible stereoisomers of terminally protected Boc‐Val‐
Phe‐Phe‐OMe, having sequence homogeneity with Alzheimer's amyloid‐beta (Aβ18‐20) …