Supramolecular chemistry combines the strength of molecular assembly via various
molecular interactions. Hydrogen bonding facilitated self-assembly with the advantages of …

The development of innovative methodologies to identify RNA binders has attracted
enormous attention in chemical biology and drug discovery. Although antibiotics targeting …

RNA has diverse cellular functionality, including regulating gene expression, protein
translation, and cellular response to stimuli, due to its intricate structures. Over the past …

Small molecule targeting of DNA and RNA sequences has come into focus as a therapeutic
strategy for diseases such as myotonic dystrophy type 1 (DM1), a trinucleotide repeat …

Trinucleotide repeat diseases such as myotonic dystrophy type 1 (DM1) and Huntington's
disease (HD) are caused by expanded DNA repeats that can be used as templates to …

The ENCODE and genome-wide association projects have shown that much of the genome
is transcribed into RNA and much less is translated into protein. These and other functional …

Myotonic dystrophy type 1 originates from d (CTG· CAG) repeats that undergo aberrant
expansion during normal processing because the d (CTG) repeat forms stable hairpin …

RNA contributes to disease pathobiology and is an important therapeutic target. The
downstream biology of disease-causing RNAs can be short-circuited with small molecules …

Key Clinical Message Congenital myotonic dystrophy should be considered in hypotonic
infants with polyhydramniotic mothers with a positive history of myotonia. Abstract …

Small molecule targeting of nucleic acids has come into focus as a therapeutic strategy for
diseases such as myotonic dystrophy type 1 (DM1), a trinucleotide repeat disease …