Locoregional drug delivery for cancer therapy: Preclinical progress and clinical translation
Systemic drug delivery is the current clinically preferred route for cancer therapy. However,
challenges associated with tumor localization and off-tumor toxic effects limit the clinical …
challenges associated with tumor localization and off-tumor toxic effects limit the clinical …
Immunotherapy during the Immediate Perioperative Period: A Promising Approach against Metastatic Disease
E Sandbank, A Eckerling, A Margalit, L Sorski… - Current …, 2023 - mdpi.com
Tumor excision is a necessary life-saving procedure in most solid cancers. However,
surgery and the days before and following it, known as the immediate perioperative period …
surgery and the days before and following it, known as the immediate perioperative period …
Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy
G Longobardi, TL Moore, C Conte… - Wiley …, 2024 - Wiley Online Library
Polymeric nanoparticles (NPs), specifically those comprised of biodegradable and
biocompatible polyesters, have been heralded as a game‐changing drug delivery platform …
biocompatible polyesters, have been heralded as a game‐changing drug delivery platform …
[HTML][HTML] HER2-CD3-Fc Bispecific Antibody-Encoding mRNA Delivered by Lipid Nanoparticles Suppresses HER2-Positive Tumor Growth
L Hu, S Zhang, J Sienkiewicz, H Zhou, R Berahovich… - Vaccines, 2024 - mdpi.com
The human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase
receptor and tumor-associated antigen abnormally expressed in various types of cancer …
receptor and tumor-associated antigen abnormally expressed in various types of cancer …
Enhancement of immunotherapies in head and neck cancers using biomaterial-based treatment strategies
GM Sunga, J Hartgerink, AG Sikora… - Tissue Engineering Part …, 2023 - liebertpub.com
Head and neck squamous cell carcinoma (HNSCC) is a challenging disease to treat
because of typically late-stage diagnoses and tumor formation in difficult-to-treat areas …
because of typically late-stage diagnoses and tumor formation in difficult-to-treat areas …
[HTML][HTML] Single-Domain Antibodies as Antibody–Drug Conjugates: From Promise to Practice—A Systematic Review
VMM Pérez, M Baselga, AJ Schuhmacher - Cancers, 2024 - ncbi.nlm.nih.gov
Background: Antibody–drug conjugates (ADCs) represent potent cancer therapies that
deliver highly toxic drugs to tumor cells precisely, thus allowing for targeted treatment and …
deliver highly toxic drugs to tumor cells precisely, thus allowing for targeted treatment and …
Synergistic combination therapy using cowpea mosaic virus intratumoral immunotherapy and Lag-3 checkpoint blockade
Immune checkpoint therapy (ICT) for cancer can yield dramatic clinical responses; however,
these may only be observed in a minority of patients. These responses can be further limited …
these may only be observed in a minority of patients. These responses can be further limited …
Intratumoral Injection of Large Surface Area Microparticle Taxanes in Carcinomas Increases Immune Effector Cell Concentrations, Checkpoint Expression, and …
GS diZerega, HA Maulhardt, SJ Verco, AM Marin… - Oncology and …, 2024 - Springer
This review summarizes development of large surface area microparticle paclitaxel (LSAM-
PTX) and docetaxel (LSAM-DTX) for local treatment of primary carcinomas with emphasis on …
PTX) and docetaxel (LSAM-DTX) for local treatment of primary carcinomas with emphasis on …
The Power of Nanovaccines in Immunotherapy of Melanoma, Lung, Breast, and Colon Cancers: A Comprehensive Review
SG Angaji, MA Salim, A Azizi, N Amiri… - … in Biotechnology and …, 2023 - rbes.rovedar.com
Scientists are exploring new approaches to overcome cancer, and nanovaccines have
emerged as one of the most promising tools in the fight against cancer. This review aimed to …
emerged as one of the most promising tools in the fight against cancer. This review aimed to …
Cancer therapy via neoepitope-specific monoclonal antibody cocktails
CJ Hartman, AO Mohamed, GS Shukla, SC Pero… - bioRxiv, 2024 - biorxiv.org
Background: Cellular heterogeneity presents a significant challenge to cancer treatment.
Antibody therapies targeting individual tumor-associated antigens can be extremely effective …
Antibody therapies targeting individual tumor-associated antigens can be extremely effective …