Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017 - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

[HTML][HTML] Amelogenesis imperfecta; genes, proteins, and pathways

CEL Smith, JA Poulter, A Antanaviciute… - Frontiers in …, 2017 - frontiersin.org
Amelogenesis imperfecta (AI) is the name given to a heterogeneous group of conditions
characterized by inherited developmental enamel defects. AI enamel is abnormally thin, soft …

[HTML][HTML] Protein-mediated enamel mineralization

J Moradian-Oldak - Frontiers in bioscience: a journal and virtual …, 2012 - ncbi.nlm.nih.gov
Enamel is a hard nanocomposite bioceramic with significant resilience that protects the
mammalian tooth from external physical and chemical damages. The remarkable …

Stem cells for tooth engineering.

G Bluteau, HU Luder, C De Bari… - European cells and …, 2008 - zora.uzh.ch
Tooth development results from sequential and reciprocal interactions between the oral
epithelium and the underlying neural crest-derived mesenchyme. The generation of dental …

Cenozoic megatooth sharks occupied extremely high trophic positions

ER Kast, ML Griffiths, SL Kim, ZC Rao, K Shimada… - Science …, 2022 - science.org
Trophic position is a fundamental characteristic of animals, yet it is unknown in many extinct
species. In this study, we ground-truth the 15N/14N ratio of enameloid-bound organic matter …

Osteopontin splice variants and polymorphisms in cancer progression and prognosis

MA Briones-Orta, SE Avendaño-Vázquez… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Osteopontin (OPN) is an extracellular matrix protein that is overexpressed in various cancers
and promotes oncogenic features including cell proliferation, survival, migration, and …

Biomineralization in humans: making the hard choices in life

K Kawasaki, AV Buchanan… - Annual review of genetics, 2009 - annualreviews.org
The skeleton, teeth, and otoconia are normally the only mineralized tissues or organs in the
human body. We describe physiological biomineralization in collagenous matrices as well …

Cell fate determination during tooth development and regeneration

TA Mitsiadis, D Graf - Birth Defects Research Part C: Embryo …, 2009 - Wiley Online Library
Teeth arise from sequential and reciprocal interactions between the oral epithelium and the
underlying cranial neural crest‐derived mesenchyme. Their formation involves a precisely …

The enamel protein amelotin is a promoter of hydroxyapatite mineralization

N Abbarin, S San Miguel, J Holcroft… - Journal of Bone and …, 2015 - academic.oup.com
Amelotin (AMTN) is a recently discovered protein that is specifically expressed during the
maturation stage of dental enamel formation. It is localized at the interface between the …

[HTML][HTML] Molecular Decay of the Tooth Gene Enamelin (ENAM) Mirrors the Loss of Enamel in the Fossil Record of Placental Mammals

RW Meredith, J Gatesy, WJ Murphy, OA Ryder… - PLoS …, 2009 - journals.plos.org
Vestigial structures occur at both the anatomical and molecular levels, but studies
documenting the co-occurrence of morphological degeneration in the fossil record and …