In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …

Many thousands of lipid species exist and their metabolism is interwoven via numerous
pathways and networks. These networks can also change in response to cellular …

It is increasingly acknowledged that a sex and gender specificity affects the occurrence,
development, and consequence of a plethora of pathologies. Mitochondria are considered …

Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …

Mitochondria are essential components of eukaryotic cells and are involved in a diverse set
of cellular processes that include ATP production, cellular signalling, apoptosis and cell …

Rationale: Barth syndrome is an X-linked cardiac and skeletal myopathy caused by mutation
of the gene Tafazzin (TAZ). Currently, there is no targeted treatment for Barth syndrome …

Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and
remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL …

Mitochondrial dysfunction has been established as a common feature of neurodegenerative
disorders that contributes to disease pathology by causing impaired cellular energy …

Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of
phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles …

Much is known, but there is also much more to discover, about the actions that thyroid
hormones (TH) exert on metabolism. Indeed, despite the fact that thyroid hormones are …