The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in
maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data …

Thrombomodulin (TM) is a 557-amino acid protein with a broad cell and tissue distribution
consistent with its wide-ranging physiological roles. When expressed on the lumenal surface …

See also Borissoff JI, ten Cate H. From neutrophil extracellular traps release to thrombosis:
an overshooting host‐defense mechanism? This issue, pp 1791–4. Summary Background …

Thrombin is the final protease generated in the blood coagulation cascade, and is the only
factor capable of cleaving fibrinogen to create a fibrin clot. Unlike every other coagulation …

The protein C anticoagulant system generates an “on demand” physiologic anticoagulant
response. The pathway is initiated when thrombin binds to the endothelial cell thrombin …

Adherence of Plasmodium falciparum-infected erythrocytes to cerebral postcapillary venular
endothelium is believed to be a critical step in the development of cerebral malaria. Some of …

In a classic experiment, Esmon and Owen discovered thrombomodulin by asking how
protein C, a vitamin K dependent protease zymogotr, might be a physiologic anticoagulant …

Recent studies have revealed a correlation between amino acid sequences around
glycosylation sites in proteoglycans and the ability of cells to initiate and process …

Endothelial cells perform key homeostatic functions such as regulating blood flow,
permeability, and aiding immune surveillance for pathogens. While endothelial activation …

Hyperfibrinolysis is thought to contribute to bleeding associated with advanced cirrhosis.
Thrombin activatable fibrinolysis inhibitor (TAFI) is a plasma precursor of a …