The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family
Abstract The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs)
enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that …
enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that …
[HTML][HTML] Metalloproteinases: A parade of functions in matrix biology and an outlook for the future
Abstract This issue of Matrix Biology is devoted to exploring how metalloproteinases–here
inclusive of related families of extracellular proteinases–act on extracellular matrix (ECM) …
inclusive of related families of extracellular proteinases–act on extracellular matrix (ECM) …
ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
J Bernier-Latmani, C Mauri, R Marcone… - Nature …, 2022 - nature.com
The small intestinal villus tip is the first point of contact for lumen-derived substances
including nutrients and microbial products. Electron microscopy studies from the early 1970s …
including nutrients and microbial products. Electron microscopy studies from the early 1970s …
Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair
TJ Keane, CM Horejs, MM Stevens - Advanced drug delivery reviews, 2018 - Elsevier
All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging
from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most …
from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most …
Cross-species insights into genomic adaptations to hypoxia
ME Pamenter, JE Hall, Y Tanabe… - Frontiers in Genetics, 2020 - frontiersin.org
Over millions of years, vertebrate species populated vast environments spanning the globe.
Among the most challenging habitats encountered were those with limited availability of …
Among the most challenging habitats encountered were those with limited availability of …
ADAMTS12 promotes oxaliplatin chemoresistance and angiogenesis in gastric cancer through VEGF upregulation
Y Jiang, J Huang, Z Huang, W Li, R Tan, T Li, Z Chen… - Cellular …, 2023 - Elsevier
Abstract Background While ADAMTS12 (A disintegrin and metalloproteinase with
thrombospondin motifs 12) has been established as an important regulator of …
thrombospondin motifs 12) has been established as an important regulator of …
ADAMTS8 promotes the development of pulmonary arterial hypertension and right ventricular failure: a possible novel therapeutic target
J Omura, K Satoh, N Kikuchi, T Satoh… - Circulation …, 2019 - Am Heart Assoc
Rationale: Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular
remodeling with aberrant pulmonary artery smooth muscle cells (PASMCs) proliferation …
remodeling with aberrant pulmonary artery smooth muscle cells (PASMCs) proliferation …
Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia
H Qu, RA Khalil - Biochemical Pharmacology, 2022 - Elsevier
Normal pregnancy (NP) involves intricate processes starting with egg fertilization,
proceeding to embryo implantation, placentation and gestation, and culminating in …
proceeding to embryo implantation, placentation and gestation, and culminating in …
Molecular regulation of sprouting angiogenesis
The term angiogenesis arose in the 18th century. Several studies over the next 100 years
laid the groundwork for initial studies performed by the Folkman laboratory, which were at …
laid the groundwork for initial studies performed by the Folkman laboratory, which were at …
ADAMs family and relatives in cardiovascular physiology and pathology
A disintegrin and metalloproteinases (ADAMs) are a family of membrane-bound proteases.
ADAM-TSs (ADAMs with thrombospondin domains) are a close relative of ADAMs that are …
ADAM-TSs (ADAMs with thrombospondin domains) are a close relative of ADAMs that are …