Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-κB through a targetable second interaction with upstream activator IKK2
Canonical NF-κB signaling through the inhibitor of κB kinase (IKK) complex requires
induction of IKK2/IKKβ subunit catalytic activity via specific phosphorylation within its …
induction of IKK2/IKKβ subunit catalytic activity via specific phosphorylation within its …
Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth
JV Napoleon, S Sagar, SP Kubica… - Proceedings of the …, 2022 - National Acad Sciences
Activation of inhibitor of nuclear factor NF-κB kinase subunit-β (IKKβ), characterized by
phosphorylation of activation loop serine residues 177 and 181, has been implicated in the …
phosphorylation of activation loop serine residues 177 and 181, has been implicated in the …
Identification of Autophagy-Related Targets of Berberine against Non-Small Cell Lung Cancer and Their Correlation with Immune Cell Infiltration By Combining …
L Xu - Critical Reviews™ in Immunology, 2023 - dl.begellhouse.com
Objective: Non-small cell lung cancer (NSCLC) is the most common lung cancer type with
high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and …
high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and …
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy
Genetic models validated Inhibitor of nuclear factor (NF) kappa B kinase beta (IKKβ) as a
therapeutic target for KRAS mutation associated pancreatic cancer. Phosphorylation of the …
therapeutic target for KRAS mutation associated pancreatic cancer. Phosphorylation of the …
Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA
S Kour, S Rana, S Kizhake, D Lagundžin… - RSC Chemical …, 2022 - pubs.rsc.org
Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-κB subunit RELA has
been implicated in several pathological conditions. Here we report the discovery of a …
been implicated in several pathological conditions. Here we report the discovery of a …
Virtual structure-based docking and molecular dynamics of FDA-approved drugs for the identification of potential IKKB inhibitors possessing dopaminergic activity in …
In Alzheimer's disease (AD), neuroinflammation is detrimental in causing
neurodegeneration. In the central nervous system, inhibitor of nuclear factor kappa B kinase …
neurodegeneration. In the central nervous system, inhibitor of nuclear factor kappa B kinase …
Fluorescence based live cell imaging identifies exon 14 skipped hepatocyte growth factor receptor (MET) degraders
JR Mallareddy, L Yang, WH Lin, R Feathers… - bioRxiv, 2024 - biorxiv.org
Despite ongoing efforts to employ structure-based methods to discover targeted protein
degraders (TPD), the prevailing strategy continues to be the synthesis of a focused set of …
degraders (TPD), the prevailing strategy continues to be the synthesis of a focused set of …
Idenification of autophagy-related targets of berberine against non-small cell lung cancer by combining network pharmacology, molecular docking, and experimental …
L Xu - Critical Reviews™ in Immunology - dl.begellhouse.com
Objective: Non-small cell lung cancer (NSCLC) is the most common lung cancer type with
high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and …
high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and …