Background. The relationship between mobility and cognition in aging is well established,
but the relationship between mobility and the structure and function of the aging brain is …

White matter changes occur endemically in routine magnetic resonance imaging (MRI)
scans of elderly persons. MRI appearance and histopathological correlates of white matter …

Gait disturbances are common in the elderly. Cerebral small vessel disease, including white
matter lesions and lacunars infarcts, is thought to disrupt white matter tracts that connect …

There are currently more than 38.9 million people aged 65 an older in the United States. Up
to 3.6 million of these people are considered housebound and in need of home‐based care …

Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive
function in late life, but the neural correlates for these relationships are unclear. To study …

Background Gait impairment contributes to falls and frailty. Some studies suggest that
cerebral small vessel disease (CSVD) is associated with gait impairment in the general …

Animal models of stroke demonstrated that white matter ischemia may cause both axonal
damage and myelin degradation distant from the core lesion, thereby impacting on behavior …

Gait disorders are common in the course of dementia, even at the stage of mild cognitive
impairment, owing to probable changes in higher levels of motor control. Since motor control …

Age‐related white matter changes (WMC) are considered manifestation of arteriolosclerotic
small vessel disease and are related to age and vascular risk factors. Most recent studies …

Objective: To investigate the topographic changes of white matter (WM) integrity and cortical
thickness related to gait disturbances and determine whether these neural correlates …