The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

The generation of neurons in the adult mammalian brain requires the activation of quiescent
neural stem cells (NSCs). This activation and the sequential steps of neuron formation from …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Neurogenic regions of mammalian brain produce many more neurons that will eventually
survive and reach a mature stage. Developmental cell death affects both embryonically …

The cerebellum is a key player in many brain functions and a major topic of neuroscience
research. However, the cerebellar nuclei (CN), the main output structures of the cerebellum …

Spinal cord injury (SCI) can lead to permanent and severe functional impairment below the
lesion level and is still one of the most challenging clinical problems. The treatment of SCI …

Erythroblastic islands (EBIs), discovered more than 60 years ago, are specialized
microenvironments for erythropoiesis. This island consists of a central macrophage with …

Microglia play a crucial role in interacting with neuronal synapses and modulating synaptic
plasticity. This function is particularly significant during postnatal development, as microglia …

It is commonly known that the insulin-like growth factor-I gene contains six exons that can be
differentially spliced to create multiple transcript variants. Further, there are two mutually …

By serving as the sole output of the cerebellar cortex, integrating a myriad of afferent stimuli,
Purkinje cells (PCs) constitute the principal neuron in cerebellar circuits. Several …