Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

Women are at twice the risk for anxiety and depression disorders as men are, although the
underlying biological factors and mechanisms are largely unknown. In this review, we …

Metabolic reprogramming is a hallmark of activated T cells. The switch from oxidative
phosphorylation to aerobic glycolysis provides energy and intermediary metabolites for the …

Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering
therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages …

Enhancer elements are genomic regulatory sequences that direct the selective expression
of genes so that genetically identical cells can differentiate and acquire the highly …

Joint profiling of chromatin accessibility and gene expression from the same single cell
provides critical information about cell types in a tissue and cell states during a dynamic …

T-cell exhaustion is a progressive loss of effector function and memory potential due to
persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we …

Summary Store-operated Ca 2+ entry (SOCE) is the main Ca 2+ influx pathway in
lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) is widely
used to identify regulatory regions throughout the genome. However, very few studies have …

The efficacy of the adaptive immune response declines markedly with age, but the cell-
intrinsic mechanisms driving immune aging in humans remain poorly understood. Immune …