Effect-directed analysis supporting monitoring of aquatic environments—an in-depth overview
Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …
pose a risk to ecosystems and human health. This contamination cannot be addressed with …
The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates
JA Kramer, JE Sagartz, DL Morris - Nature Reviews Drug Discovery, 2007 - nature.com
Toxicity is a leading cause of attrition at all stages of the drug development process. The
majority of safety-related attrition occurs preclinically, suggesting that approaches to …
majority of safety-related attrition occurs preclinically, suggesting that approaches to …
[图书][B] Bioanalytical tools in water quality assessment
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …
The field has exploded since and the second edition updates and reviews the application of …
No time to lose—high throughput screening to assess nanomaterial safety
Nanomaterials hold great promise for medical, technological and economical benefits.
Knowledge concerning the toxicological properties of these novel materials is typically …
Knowledge concerning the toxicological properties of these novel materials is typically …
Screening of medicinal plants used in South African traditional medicine for genotoxic effects
EE Elgorashi, JLS Taylor, A Maes, J van Staden… - Toxicology letters, 2003 - Elsevier
Dichloromethane and 90% methanol extracts from 51 South African medicinal plants were
evaluated for potential genotoxic effects using the bacterial Ames and VITOTOX® tests with …
evaluated for potential genotoxic effects using the bacterial Ames and VITOTOX® tests with …
Mutagenic and antimutagenic properties of extracts from South African traditional medicinal plants
L Verschaeve, J Van Staden - Journal of Ethnopharmacology, 2008 - Elsevier
AIM OF THE STUDY: The aim of this paper was to summarize the results of our
investigations on the in vitro genotoxic as well as antigenotoxic effects of a great number of …
investigations on the in vitro genotoxic as well as antigenotoxic effects of a great number of …
Decolorization, cytotoxicity, and genotoxicity reduction during a combined ozonation/fungal treatment of dye-contaminated wastewater
S Vanhulle, M Trovaslet, E Enaud… - Environmental …, 2008 - ACS Publications
In view of compliance with increasingly stringent environmental legislation imposed by
regional, national, and supranational (eg, European Union) authorities, innovative …
regional, national, and supranational (eg, European Union) authorities, innovative …
Improved bacterial SOS promoter∷ lux fusions for genotoxicity detection
Y Davidov, R Rozen, DR Smulski, TK Van Dyk… - … /Genetic Toxicology and …, 2000 - Elsevier
Escherichia coli strains containing plasmid-borne fusions of Vibrio fischeri lux to the recA
promoter–operator region were previously shown to be potentially useful for detecting …
promoter–operator region were previously shown to be potentially useful for detecting …
Biotests for environmental quality assessment of composted sewage sludge
A Kapanen, M Vikman, J Rajasärkkä, M Virta… - Waste Management, 2013 - Elsevier
The quality of sewage sludge-based products, such as composts and growth media, is
affected by the contamination of sewage sludge with, potentially, hundreds of different …
affected by the contamination of sewage sludge with, potentially, hundreds of different …
Bioluminescent whole cell optical fiber sensor to genotoxicants: system optimization
An Escherichia coli strain, genetically modified to emit a luminescent signal in the presence
of genotoxic agents, was alginate-immobilized onto an exposed core of a fiber-optic. The …
of genotoxic agents, was alginate-immobilized onto an exposed core of a fiber-optic. The …