Effect-directed analysis supporting monitoring of aquatic environments—an in-depth overview

W Brack, S Ait-Aissa, RM Burgess, W Busch… - Science of the Total …, 2016 - Elsevier
Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …

The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates

JA Kramer, JE Sagartz, DL Morris - Nature Reviews Drug Discovery, 2007 - nature.com
Toxicity is a leading cause of attrition at all stages of the drug development process. The
majority of safety-related attrition occurs preclinically, suggesting that approaches to …

[图书][B] Bioanalytical tools in water quality assessment

P Neale, F Leusch, B Escher - 2021 - library.oapen.org
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …

No time to lose—high throughput screening to assess nanomaterial safety

R Damoiseaux, S George, M Li, S Pokhrel, Z Ji… - Nanoscale, 2011 - pubs.rsc.org
Nanomaterials hold great promise for medical, technological and economical benefits.
Knowledge concerning the toxicological properties of these novel materials is typically …

Screening of medicinal plants used in South African traditional medicine for genotoxic effects

EE Elgorashi, JLS Taylor, A Maes, J van Staden… - Toxicology letters, 2003 - Elsevier
Dichloromethane and 90% methanol extracts from 51 South African medicinal plants were
evaluated for potential genotoxic effects using the bacterial Ames and VITOTOX® tests with …

Mutagenic and antimutagenic properties of extracts from South African traditional medicinal plants

L Verschaeve, J Van Staden - Journal of Ethnopharmacology, 2008 - Elsevier
AIM OF THE STUDY: The aim of this paper was to summarize the results of our
investigations on the in vitro genotoxic as well as antigenotoxic effects of a great number of …

Decolorization, cytotoxicity, and genotoxicity reduction during a combined ozonation/fungal treatment of dye-contaminated wastewater

S Vanhulle, M Trovaslet, E Enaud… - Environmental …, 2008 - ACS Publications
In view of compliance with increasingly stringent environmental legislation imposed by
regional, national, and supranational (eg, European Union) authorities, innovative …

Improved bacterial SOS promoter∷ lux fusions for genotoxicity detection

Y Davidov, R Rozen, DR Smulski, TK Van Dyk… - … /Genetic Toxicology and …, 2000 - Elsevier
Escherichia coli strains containing plasmid-borne fusions of Vibrio fischeri lux to the recA
promoter–operator region were previously shown to be potentially useful for detecting …

Biotests for environmental quality assessment of composted sewage sludge

A Kapanen, M Vikman, J Rajasärkkä, M Virta… - Waste Management, 2013 - Elsevier
The quality of sewage sludge-based products, such as composts and growth media, is
affected by the contamination of sewage sludge with, potentially, hundreds of different …

Bioluminescent whole cell optical fiber sensor to genotoxicants: system optimization

B Polyak, E Bassis, A Novodvorets, S Belkin… - Sensors and Actuators B …, 2001 - Elsevier
An Escherichia coli strain, genetically modified to emit a luminescent signal in the presence
of genotoxic agents, was alginate-immobilized onto an exposed core of a fiber-optic. The …