Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Photopolymerizable biomaterials and light-based 3D printing strategies for biomedical applications

C Yu, J Schimelman, P Wang, KL Miller, X Ma… - Chemical …, 2020 - ACS Publications
Since the advent of additive manufacturing, known commonly as 3D printing, this technology
has revolutionized the biofabrication landscape and driven numerous pivotal advancements …

Caged compounds: photorelease technology for control of cellular chemistry and physiology

GCR Ellis-Davies - Nature methods, 2007 - nature.com
Caged compounds are light-sensitive probes that functionally encapsulate biomolecules in
an inactive form. Irradiation liberates the trapped molecule, permitting targeted perturbation …

Biologically active molecules with a “light switch”

G Mayer, A Heckel - Angewandte Chemie International Edition, 2006 - Wiley Online Library
Biologically active compounds which are light‐responsive offer experimental possibilities
which are otherwise very difficult to achieve. Since light can be manipulated very precisely …

Light-triggered release of photocaged therapeutics-Where are we now?

JM Silva, E Silva, RL Reis - Journal of Controlled Release, 2019 - Elsevier
The current available therapeutics face several challenges such as the development of ideal
drug delivery systems towards the goal of personalized treatments for patients benefit. The …

From one‐photon to two‐photon probes:“Caged” compounds, actuators, and photoswitches

G Bort, T Gallavardin, D Ogden… - Angewandte Chemie …, 2013 - Wiley Online Library
Molecular systems that can be remotely controlled by light are gaining increasing
importance in cell biology, physiology, and neurosciences because of the spatial and …

Illuminating the chemistry of life: design, synthesis, and applications of “caged” and related photoresponsive compounds

HM Lee, DR Larson, DS Lawrence - ACS chemical biology, 2009 - ACS Publications
Biological systems are characterized by a level of spatial and temporal organization that
often lies beyond the grasp of present day methods. Light-modulated bioreagents, including …

Chemistry and biological applications of photo-labile organic molecules

H Yu, J Li, D Wu, Z Qiu, Y Zhang - Chemical Society Reviews, 2010 - pubs.rsc.org
Photo-labile molecules have been widely used not only in organic synthesis but also in
biological study. The chemistry of the typical photo-labile organic molecules, including their …

Applications of p-hydroxyphenacyl (p HP) and coumarin-4-ylmethyl photoremovable protecting groups

RS Givens, M Rubina, J Wirz - Photochemical & Photobiological …, 2012 - pubs.rsc.org
Most applications of photoremovable protecting groups have used o-nitrobenzyl compounds
and their (often commercially available) derivatives that, however, have several …

Genetically encoded optochemical probes for simultaneous fluorescence reporting and light activation of protein function with two-photon excitation

J Luo, R Uprety, Y Naro, C Chou… - Journal of the …, 2014 - ACS Publications
The site-specific incorporation of three new coumarin lysine analogues into proteins was
achieved in bacterial and mammalian cells using an engineered pyrrolysyl-tRNA synthetase …