Toxin-derived peptides: An unconventional approach to alleviating cerebral stroke burden and neurobehavioral impairments

SM Mumtaz, MA Khan, A Jamal, SH Hattiwale… - Life Sciences, 2024 - Elsevier
Cerebral stroke is a pressing global health concern, ranking as the second leading cause of
mortality and resulting in persistent neurobehavioral impairments. Cerebral strokes …

[PDF][PDF] Pregnenolone protects the liver against doxorubicin-induced cellular injury by anti-inflammatory, antioxidant, and antiapoptotic mechanisms: role of Keap1/Nrf2 …

MA Morsy, M El-Daly, BA Kamel… - European Review for …, 2023 - europeanreview.org
OBJECTIVE: Doxorubicin (DOX) is a widely used cytotoxic anthracycline antibiotic
characterized by increased adverse effects that limit its clinical usefulness. Pregnenolone is …

Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis—Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1

MA Morsy, SA Abdel-Gaber, SA Mokhemer… - Pharmaceuticals, 2023 - mdpi.com
The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as
cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in …

[HTML][HTML] The results of a unique dietary supplement (nutraceutical formulation) used to treat the symptoms of long-haul COVID

NB Gaylis, I Kreychman, J Sagliani, J Mograbi… - Frontiers in …, 2022 - frontiersin.org
Long-COVID is a syndrome characterized by debilitating symptoms that persist over 3
months after infection with the SARS-CoV-2 virus. It affects 15 to 33% of COVID-19 …

Hyperthermia alters neurobehavior by affecting cell proliferation and neuronal survival in young male rats

F Mete, S Eyuboglu, A Vitrinel, U Kilic… - International Journal …, 2023 - Wiley Online Library
Maintenance of body temperature within physiological range is critical for the fetal and
neonatal development. Hyperthermia is one of the most frequently encountered pediatric …

[PDF][PDF] Synthetic neuroactive steroids.

Š Alušík, Z Paluch, D Kalátová - Neuro Endocrinology Letters, 2024 - nel.edu
This review discusses the topic of synthetic neuroactive steroids. A brief introduction to the
mode of action of neuroactive steroids is followed by a short overview of the best-known …

[HTML][HTML] The Ability of Pregnenolone in Proliferation of Mouse Neural Stem Cells and Reduction of Inflammatory and Oxidant Markers after Induction of Inflammation …

K Negintaji, M Foroozanfar, M Jafarinia… - Armaghane …, 2023 - armaghanj.yums.ac.ir
Background & aim: Pregnenolone acts as a precursor to other steroid hormones and exerts
its effect as an anti-inflammatory molecule to maintain immune homeostasis in various …

توانمندی پرگنونولون در تکثیر سلول‌های بنیادی عصبی موشی و کاستن نشانگرهای التهابی و اکسیدانی پس از القای التهاب با لیپوپلی ساکارید در شرایط آزمایشگاهی

نگین تاجی, کوروش, فروزان فر, محسن, جعفرنیا… - ارمغان دانش, 2023‎ - armaghanj.yums.ac.ir
روش بررسی: در این مطالعه تجربی که در سال 1399 در دانشگاه علوم پزشکی یاسوج انجام شد،
سلول‌های بنیادی عصبی از برجستگی‌های گانگلیونی خارجی مغز جنین 14 روزه موش سوری به روش …