Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Autophagy pathways are involved in the pathogenesis of some obesity related health
problems. As obesity is a nutrient sufficiency condition, autophagy process can be altered in …

Alkaloids are a large cluster of molecules found in Mother Nature all over the world. They
are all secondary compounds and collection of miscellaneous elements and biomolecules …

15‐Deoxy‐∆‐12, 14‐prostaglandin J2 (15d‐PGJ2), a natural peroxisome proliferator‐
activated receptor‐γ (PPAR‐γ) agonist, has been explored in some detail over the last 20 …

Nicotinamide adenine dinucleotide (NAD+) is an essential biomolecule involved in many
critical processes. Its role as both a driver of energy production and a signaling molecule …

Histone deacetylases (HDACs) are enzymes that play a role in chromatin remodeling and
epigenetics. They belong to a specific category of enzymes that eliminate the acetyl part of …

Transcriptional factor EB (TFEB), a master regulator of autophagy and lysosomal
biogenesis, is generally regarded as a pro-survival factor. Here, we identify that besides its …

Although autophagy is a well-known and extensively described cell pathway, numerous
studies have been recently interested in studying the importance of its regulation at different …

Ovarian cancer is a common gynecological cancer that is found worldwide. Class III histone
deacetylase (HDAC) inhibitors, a new class of anticancer agents, induce autophagy in …

Sirt1–3 are the most studied sirtuins, playing a key role in caloric-dependent epigenetic
modifications. Since they are localized in distinct cellular compartments and act differently …