Although pharmacological data provide strong evidence for different types of opioid
receptors (eg, mu, delta, and kappa), they share many common properties in their ability to …

Naltrexone is an opiate antagonist used as a pharmacologic adjuvant for the treatment of
opiate and alcohol addiction. It has been hypothesized that naltrexone blocks the stress …

Substance P (SP), a member of the tachykinin family, is widely distributed in the central
nervous system and is involved in a variety of physiological processes including …

Background: Naltrexone is a long-acting opioid used clinically in alcoholism, drug abuse,
bulimia nervosa, obsessive-compulsive disorder, and impulse-control disorders. This study …

Background Low-dose naltrexone (LDN) is used widely as an off-label treatment for pain
despite limited evidence for its effectiveness. A few small trials with a high risk of bias have …

Objective This study explores dose–response relationships when treating fibromyalgia with
low-dose naltrexone. Design A single-blinded clinical trial was carried out using the “up-and …

Publisher Summary The classic neurotrophic factors, which include soluble factors such as
nerve growth factor and adhesion components such as laminin, have been defined as (1) …

This study was designed to examine the role of opioids on cell differentiation, with an
emphasis on the mechanism of opioid growth factor (OGF,[Met5]-enkephalin)-dependent …

Chronic administration of opioid antagonists has been shown to increase radioligand
binding to brain opioid receptors. The present study was conducted to determine whether …

Neurotrophins, which are structurally related to nerve growth factor, have been shown to
promote survival of various neurons. Recently, we found a novel activity of a neurotrophin in …