Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out
during the pathogenesis of the disease and in turn modulates disease progression. The …

Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in
the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer …

Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer's
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …

A major feature of Alzheimer's disease (AD) pathology is the plaque composed of
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …