Oral mucosal epithelial cells

S Groeger, J Meyle - Frontiers in immunology, 2019 - frontiersin.org
Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the
organism from chemical, microbial, and physical challenges which is indispensable for …

Lactoferrin in a context of inflammation-induced pathology

ML Kruzel, M Zimecki, JK Actor - Frontiers in immunology, 2017 - frontiersin.org
Much progress has been achieved to elucidate the function of lactoferrin (LTF), an iron-
binding glycoprotein, in the milieu of immune functionality. This review represents a unique …

Function of Nod‐like receptors in microbial recognition and host defense

L Franchi, N Warner, K Viani… - Immunological reviews, 2009 - Wiley Online Library
Nucleotide oligomerization domain (NOD)‐like receptors (NLRs) are a specialized group of
intracellular proteins that play a critical role in the regulation of the host innate immune …

Macrophages in tuberculosis: friend or foe

E Guirado, LS Schlesinger, G Kaplan - Seminars in immunopathology, 2013 - Springer
Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Peptidoglycan recognition proteins: modulators of the microbiome and inflammation

J Royet, D Gupta, R Dziarski - Nature Reviews Immunology, 2011 - nature.com
All animals, including humans, live in symbiotic association with microorganisms. The
immune system accommodates host colonization by the microbiota, maintains microbiota …

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders

M Fukata, AS Vamadevan, MT Abreu - Seminars in immunology, 2009 - Elsevier
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are two major forms of innate
immune sensors, which provide immediate responses against pathogenic invasion or tissue …

Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences

J Royet, R Dziarski - Nature Reviews Microbiology, 2007 - nature.com
Peptidoglycan recognition proteins (PGRPs) are innate immunity molecules that are present
in most invertebrate and vertebrate animals. All PGRPs function in antimicrobial defence …

Cytokine-mediated regulation of antimicrobial proteins

JK Kolls, PB McCray Jr, YR Chan - Nature Reviews Immunology, 2008 - nature.com
Antimicrobial proteins constitute a phylogenetically ancient form of innate immunity that
provides host defence at skin and mucosal surfaces. Although some components of this …

The peptidoglycan recognition proteins (PGRPs)

R Dziarski, D Gupta - Genome biology, 2006 - Springer
Peptidoglycan recognition proteins (PGRPs) are innate immunity molecules present in
insects, mollusks, echinoderms, and vertebrates, but not in nematodes or plants. PGRPs …

Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines

A Uehara, Y Fujimoto, K Fukase, H Takada - Molecular immunology, 2007 - Elsevier
Epithelial cells may form the first barrier of defense against bacteria in human tissues. We
recently revealed that oral epithelial cells generated anti-bacterial factors, such as …