Neurodegenerative diseases have two general characteristics that are so fundamental we
usually take them for granted. The first is that the pathology associated with the disease only …

The demand for organ transplantation and repair, coupled with a shortage of available
donors, poses an urgent clinical need for the development of innovative treatment strategies …

Recent research reporting successful translation of stem cell therapies to patients have
enriched the hope that such regenerative strategies may one day become a treatment for a …

Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …

Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …

Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of striatal
dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the …

Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

The discovery of methods to convert somatic cells into induced pluripotent stem cells
(iPSCs) through expression of a small combination of transcription factors has raised the …

Stem‐cell‐based therapies have the potential to provide novel solutions for the treatment of
a variety of diseases, but the main obstacles to such therapies lie in the uncontrolled …