Emerging roles of astrocytes as immune effectors in the central nervous system
TM Fisher, SA Liddelow - Trends in Immunology, 2024 - cell.com
The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded
as a functionally diverse mediator of homeostasis. During development and throughout …
as a functionally diverse mediator of homeostasis. During development and throughout …
[HTML][HTML] Extracellular vesicles from neural stem cells safeguard neurons in intracerebral hemorrhage by suppressing reactive astrocyte neurotoxicity
T Li, L Zhang, P Wang, J Yu, J Zhong, Q Tang, T Zhu… - Cell Reports, 2024 - cell.com
Extracellular vesicles (EVs) derived from stem cells have shown therapeutic potential in
various diseases, but their use in treating neurological disorders remains limited. In this …
various diseases, but their use in treating neurological disorders remains limited. In this …
Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astrocytes Reveals Novel Functions in the Adult Cerebral Cortex
P Natarajan, C Koupourtidou, T de Resseguier… - Glia, 2024 - Wiley Online Library
Astrocytes play key roles in brain function, but how these are orchestrated by transcription
factors (TFs) in the adult brain and aligned with astrocyte heterogeneity is largely unknown …
factors (TFs) in the adult brain and aligned with astrocyte heterogeneity is largely unknown …
Evaluating CXCL12 for Effects on Reactive Gene Expression in Primary Astrocytes
K Zieger, C Cao, J Engele - Journal of Molecular Neuroscience, 2024 - Springer
Upon injury to the CNS, astrocytes undergo morphological and functional changes
commonly referred to as astrocyte reactivity. Notably, these reactive processes include …
commonly referred to as astrocyte reactivity. Notably, these reactive processes include …
Host and rabies virus gene expression is shaped by human brain cell type and reveals a preexisting pro-viral transcriptional state in astrocytes
L Feige, K Young, JP Cerapio, T Kozaki, L Kergoat… - bioRxiv, 2024 - biorxiv.org
Rabies virus (RABV) proteins play dual roles during the infection of complex neural tissue,
the generation and spread of new virions and the active inhibition of cellular innate immune …
the generation and spread of new virions and the active inhibition of cellular innate immune …
Anhedonic behaviour in a TLR7-driven neuroinflammation mouse model is associated with impaired thalamostriatal signalling and immune cell ingress into the brain
D Sharma, L Andrianova, R McGonigal… - bioRxiv, 2024 - biorxiv.org
Depression is a heterogenous condition driven by multiple aetiologies, which make its
pathophysiology challenging to map. Stratifying depression by underlying biological causes …
pathophysiology challenging to map. Stratifying depression by underlying biological causes …