Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Our understanding of the molecular properties of kainate receptors and their involvement in
synaptic physiology has progressed significantly over the last 30 years. A plethora of studies …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

Ionotropic neurotransmitter receptors mediate fast synaptic transmission by functioning as
ligand-gated ion channels. Fast inhibitory transmission in the brain is mediated mostly by …

In search of the molecular identities of cold-sensing receptors, we carried out an unbiased
genetic screen for cold-sensing mutants in C. elegans and isolated a mutant allele of glr-3 …

The gastropod mollusk Aplysia is an important model for cellular and molecular
neurobiological studies, particularly for investigations of molecular mechanisms of learning …

Many animal tissues/cells are photosensitive, yet only two types of photoreceptors (ie,
opsins and cryptochromes) have been discovered in metazoans. The question arises as to …

l-Glutamate is the main excitatory neurotransmitter in the brain, with postsynaptic responses
to its release predominantly mediated by AMPA-type glutamate receptors (AMPARs). A …

A primary determinant of the strength of neurotransmission is the number of AMPA-type
glutamate receptors (AMPARs) at synapses. However, we still lack a mechanistic …

Excitatory glutamatergic synaptic transmission is critically dependent on maintaining an
optimal number of postsynaptic AMPA receptors (AMPARs) at each synapse of a given …