Improving cancer treatments via dynamical biophysical models

M Kuznetsov, J Clairambault, V Volpert - Physics of life reviews, 2021 - Elsevier
Despite significant advances in oncological research, cancer nowadays remains one of the
main causes of mortality and morbidity worldwide. New treatment techniques, as a rule …

The origin of RNA interference: Adaptive or neutral evolution?

A Torri, J Jaeger, T Pradeu, MC Saleh - PLoS Biology, 2022 - journals.plos.org
The origin of RNA interference (RNAi) is usually explained by a defense-based hypothesis,
in which RNAi evolved as a defense against transposable elements (TEs) and RNA viruses …

[HTML][HTML] Cell plasticity in cancer cell populations

S Shen, J Clairambault - F1000Research, 2020 - ncbi.nlm.nih.gov
Cell plasticity in cancer cell populations - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …

Groundwork for AI: Enforcing a benchmark for neoantigen prediction in personalized cancer immunotherapy

F Jaton - Social Studies of Science, 2023 - journals.sagepub.com
This article expands on recent studies of machine learning or artificial intelligence (AI)
algorithms that crucially depend on benchmark datasets, often called 'ground truths.'These …

Minding the gut: extending embodied cognition and perception to the gut complex

F Boem, GP Greslehner, JP Konsman… - Frontiers in …, 2024 - frontiersin.org
Scientific and philosophical accounts of cognition and perception have traditionally focused
on the brain and external sense organs. The extended view of embodied cognition suggests …

A part‐dependent account of biological individuality: why holobionts are individuals and ecosystems simultaneously

J Suárez, A Stencel - Biological Reviews, 2020 - Wiley Online Library
Given one conception of biological individuality (evolutionary, physiological, etc.), can a
holobiont–that is the host+ its symbiotic (mutualistic, commensalist and parasitic) …

Immune checkpoint inhibitors promising role in cancer therapy: Clinical evidence and immune-related adverse events

SM Meybodi, B Farasati Far, A Pourmolaei… - Medical Oncology, 2023 - Springer
The advent of immune checkpoint inhibitors (ICIs) has led to noteworthy progressions in the
management of diverse cancer types, as evidenced by the pioneering “ipilimumab” …

Immunitarianism: defence and sacrifice in the politics of Covid-19

B Ajana - History and Philosophy of the Life Sciences, 2021 - Springer
As witnessed over the last year, immunity emerged as one of most highly debated topics in
the current Covid-19 pandemic. Countries around the globe have been debating whether …

Reuniting philosophy and science to advance cancer research

T Pradeu, B Daignan‐Fornier, A Ewald… - Biological …, 2023 - Wiley Online Library
Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many
biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task …

The conceptual foundations of innate immunity: Taking stock 30 years later

T Pradeu, BPHJ Thomma, SE Girardin, B Lemaitre - Immunity, 2024 - cell.com
While largely neglected over decades during which adaptive immunity captured most of the
attention, innate immune mechanisms have now become central to our understanding of …