Structure of the neurotensin receptor 1 in complex with β-arrestin 1
Arrestin proteins bind to active, phosphorylated G-protein-coupled receptors (GPCRs),
thereby preventing G-protein coupling, triggering receptor internalization and affecting …
thereby preventing G-protein coupling, triggering receptor internalization and affecting …
[HTML][HTML] Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
Binding of arrestin to phosphorylated G protein-coupled receptors (GPCRs) is crucial for
modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins …
modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins …
Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives
The development of small-molecule inhibitors targeting G protein-coupled receptor kinase 2
(GRK2) and G protein-coupled receptor kinase 5 (GRK5) for the treatment of chronic …
(GRK2) and G protein-coupled receptor kinase 5 (GRK5) for the treatment of chronic …
Targeting G protein–coupled receptor kinases to G protein–coupled receptors
SM Sulon, JL Benovic - Current opinion in endocrine and metabolic …, 2021 - Elsevier
G protein–coupled receptors (GPCRs) interact with three protein families after agonist
binding: heterotrimeric G proteins, G protein–coupled receptor kinases (GRKs), and …
binding: heterotrimeric G proteins, G protein–coupled receptor kinases (GRKs), and …
GRK5 is a regulator of fibroblast activation and cardiac fibrosis
A Eguchi, R Coleman, K Gresham… - Proceedings of the …, 2021 - National Acad Sciences
Pathological remodeling of the heart is a hallmark of chronic heart failure (HF) and these
structural changes further perpetuate the disease. Cardiac fibroblasts are the critical cell …
structural changes further perpetuate the disease. Cardiac fibroblasts are the critical cell …
Negative allosteric modulation of the glucagon receptor by RAMP2
Receptor activity-modifying proteins (RAMPs) modulate the activity of many Family B
GPCRs. We show that RAMP2 directly interacts with the glucagon receptor (GCGR), a …
GPCRs. We show that RAMP2 directly interacts with the glucagon receptor (GCGR), a …
Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry
D Felker, K Lee, TH Pospiech, Y Morishima… - Journal of Biological …, 2024 - ASBMB
Neuronal nitric oxide synthase (nNOS) is a homodimeric cytochrome P450-like enzyme that
catalyzes the conversion of L-arginine to nitric oxide in the presence of NADPH and …
catalyzes the conversion of L-arginine to nitric oxide in the presence of NADPH and …
Protein tyrosine phosphatase 1B inhibitors from the fungus Malbranchea albolutea
From solid rice-based cultures of Malbranchea albolutea, three undescribed ardeemins and
sartoryglabrins analogs were discovered and named alboluteins AC. 1H-Indole-3 …
sartoryglabrins analogs were discovered and named alboluteins AC. 1H-Indole-3 …
Structure of a GRK5-calmodulin complex reveals molecular mechanism of GRK activation and substrate targeting
The phosphorylation of G protein-coupled receptors (GPCRs) by GPCR kinases (GRKs)
facilitates arrestin binding and receptor desensitization. Although this process can be …
facilitates arrestin binding and receptor desensitization. Although this process can be …
Antagonistic roles of GRK2 and GRK5 in cardiac aldosterone signaling reveal GRK5-mediated cardioprotection via mineralocorticoid receptor inhibition
J Maning, KA McCrink, CM Pollard… - International Journal of …, 2020 - mdpi.com
Aldosterone (Aldo), when overproduced, is a cardiotoxic hormone underlying heart failure
and hypertension. Aldo exerts damaging effects via the mineralocorticoid receptor (MR) but …
and hypertension. Aldo exerts damaging effects via the mineralocorticoid receptor (MR) but …