Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics
AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …
rate and has created an unprecedented health emergency around the globe. There is no …
Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
J Lei, Y Kusov, R Hilgenfeld - Antiviral research, 2018 - Elsevier
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
The discovery of poly (ADP-ribose)> 50 years ago opened a new field, leading the way for
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
Coronaviruses: an overview of their replication and pathogenesis
Abstract Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized
by club-like spikes that project from their surface, an unusually large RNA genome, and a …
by club-like spikes that project from their surface, an unusually large RNA genome, and a …
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate …
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate …
The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds
YM Báez-Santos, SES John, AD Mesecar - Antiviral research, 2015 - Elsevier
Over 10 years have passed since the deadly human coronavirus that causes severe acute
respiratory syndrome (SARS-CoV) emerged from the Guangdong Province of China …
respiratory syndrome (SARS-CoV) emerged from the Guangdong Province of China …
The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
Coronavirus pathogenesis
SR Weiss, JL Leibowitz - Advances in virus research, 2011 - Elsevier
Coronaviruses infect many species of animals including humans, causing acute and chronic
diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse …
diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse …
ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease
B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses
R Hilgenfeld, M Peiris - Antiviral research, 2013 - Elsevier
This article introduces a series of invited papers in Antiviral Research marking the 10th
anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a …
anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a …