A clinical practice guideline for the management of patients with acute spinal cord injury: recommendations on hemodynamic management

BK Kwon, LA Tetreault, AR Martin… - Global Spine …, 2024 - journals.sagepub.com
Study Design Clinical practice guideline development following the GRADE process.
Objectives Hemodynamic management is one of the only available treatment options that …

Porcine spinal cord injury model for translational research across multiple functional systems

RU Ahmed, CA Knibbe, F Wilkins, LC Sherwood… - Experimental …, 2023 - Elsevier
Animal models are necessary to identify pathological changes and help assess therapeutic
outcomes following spinal cord injury (SCI). Small animal models offer value in research in …

Detection of hypoxia by near-infrared spectroscopy and pulse oximetry: a comparative study

A Cheung, L Tu, A Macnab, BK Kwon… - Journal of biomedical …, 2022 - spiedigitallibrary.org
Significance: Pulse oximetry is widely used in clinical practice to monitor changes in arterial
oxygen saturation (SpO2). However, decreases in SpO2 can be delayed relative to the …

MicroRNA‐22‐3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5

H Fang, M Yang, Q Pan, HL Jin, HF Li… - Journal of …, 2021 - Wiley Online Library
Cell death after spinal cord ischemia/reperfusion (I/R) can occur through necrosis,
apoptosis, and autophagy, resulting in changes to the immune environment. However, the …

[HTML][HTML] Hemodynamic management of acute spinal cord injury: a literature review

YS Lee, KT Kim, BK Kwon - Neurospine, 2021 - ncbi.nlm.nih.gov
The goal of acute spinal cord injury (SCI) management is to reduce secondary injuries and
improve neurological recovery after its occurrence. This review aimed to explore the …

Management of acute spinal cord injury: Where have we been? Where are we now? Where are we going?

MG Fehlings, K Pedro, N Hejrati - Journal of Neurotrauma, 2022 - liebertpub.com
The strides that have been achieved in the realm of spinal cord injury (SCI) management are
remarkable. It is likely that 90% of what has been recognized to date about SCI …

Continuous optical monitoring of spinal cord oxygenation and hemodynamics during the first seven days post-injury in a porcine model of acute spinal cord injury

A Cheung, L Tu, N Manouchehri, KT Kim… - Journal of …, 2020 - liebertpub.com
One of the only currently available treatment options to potentially improve neurological
recovery after acute spinal cord injury (SCI) is augmentation of mean arterial blood pressure …

[HTML][HTML] Acute hyperoxia improves spinal cord oxygenation and circulatory function following cervical spinal cord injury in rats

YT Lin, EJ Gonzalez-Rothi, KZ Lee - Journal of Physiological …, 2024 - journals.lww.com
Spinal cord injury is associated with spinal vascular disruptions that result in spinal ischemia
and tissue hypoxia. This study evaluated the therapeutic efficacy of normobaric hyperoxia on …

Monitoring spinal cord hemodynamics and tissue oxygenation: a review of the literature with special focus on the near-infrared spectroscopy technique

T Rashnavadi, A Macnab, A Cheung, A Shadgan… - Spinal Cord, 2019 - nature.com
Abstract Study design Review. Objectives Clinical studies have shown that the
hemodynamic management of patients following acute spinal cord injury (SCI) is an …

[HTML][HTML] Advances and Challenges in Spinal Cord Injury Treatments

MA Alvi, KM Pedro, AI Quddusi… - Journal of Clinical …, 2024 - mdpi.com
Spinal cord injury (SCI) is a debilitating condition that is associated with long-term physical
and functional disability. Our understanding of the pathogenesis of SCI has evolved …