Photodynamic therapy (PDT) has shown promise as an effective treatment modality for
cancers and other localized diseases, such as age-related macular degeneration and …

Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low
side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for …

Photodynamic therapy (PDT) has attained extensive attention as a noninvasive tumor
treatment modality. However, the hypoxia in solid tumors, skin phototoxicity of “always on” …

The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of
photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from …

We investigated whether increasing levels of tissue hypoxia, measured by the binding of
EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2, 2, 3, 3, 3-pentafluoropropyl) acetamide] or by …

Abstract Background and Objectives Molecular oxygen in the tissue to be treated by
photodynamic therapy (PDT) is critical for photodynamic cell killing. The fluence rate of PDT …

Background: Epithelial ovarian cancer often develops resistance to standard treatments,
which is a major reason for the high mortality associated with the disease. We examined the …

The efficacy of photodynamic therapy (PDT) depends upon the delivery of both
photosensitizing drug and oxygen. In this study, we hypothesized that local vascular …

Purpose: A previous phase I trial of ip photodynamic therapy established the maximally
tolerated dose of Photofrin (Axcan Pharma, Birmingham, AL)-mediated photodynamic …

Abstract Background and Objectives Photodynamic therapy (PDT) uses a photosensitizer
activated by light, in an oxygen‐rich environment, to destroy malignant tumors. Clinical trials …