Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

Liquid–liquid phase separation results in the formation of dynamic biomolecular
condensates, also known as membrane-less organelles, that allow for the assembly of …

Mutations in autophagy genes can cause familial and sporadic amyotrophic lateral sclerosis
(ALS). However, the role of autophagy in ALS pathogenesis is poorly understood, in part …

Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease that progressively
debilitates neuronal cells that control voluntary muscle activity. Biomarkers are urgently …

In amyotrophic lateral sclerosis (ALS) the large motoneurons that innervate the fast-
contracting muscle fibers (F-type motoneurons) are vulnerable and degenerate in …

The molecular and cellular basis of selective motor neuron (MN) vulnerability in amyotrophic
lateral sclerosis (ALS) is not known. In genetically distinct mouse models of familial ALS …

Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction and
degeneration of motor neurons. Multiple disease-causing mutations, including in the genes …

Spinal cord interneurons play critical roles shaping motor output, but their precise identity
and connectivity remain unclear. Focusing on the V1 interneuron cardinal class we defined …

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of somatic motor
neurons. A major focus has been directed to motor neuron intrinsic properties as a cause for …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily targets the
motor system. Although much is known about the effects of ALS on motor neurons and glial …