Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

Epigenetic signatures underlying inflammation: An interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

O Ramos-Lopez, FI Milagro, JI Riezu-Boj… - Inflammation …, 2021 - Springer
Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

MicroRNAs in obesity and related metabolic disorders

JF Landrier, A Derghal, L Mounien - Cells, 2019 - mdpi.com
Metabolic disorders are characterized by the inability to properly use and/or store energy.
The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through …

Role of microRNAs in obesity and obesity-related diseases

G Iacomino, A Siani - Genes & nutrition, 2017 - Springer
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Q Wu, J Li, Z Li, S Sun, S Zhu, L Wang, J Wu… - Journal of Experimental …, 2019 - Springer
Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer
progression. Tumour induced beige/brown adipose tissue differentiation contributes to the …

Anti-obesity effect of carotenoids: direct impact on adipose tissue and adipose tissue-driven indirect effects

L Mounien, F Tourniaire, JF Landrier - Nutrients, 2019 - mdpi.com
This review summarizes current knowledge on the biological relevance of carotenoids and
some of their metabolites in obesity management. The relationship between carotenoids …

The impact of adipose tissue–derived miRNAs in metabolic syndrome, obesity, and cancer

GS Heyn, LH Corrêa, KG Magalhães - Frontiers in endocrinology, 2020 - frontiersin.org
Obesity is a multifactorial and complex condition that is characterized by abnormal and
excessive white adipose tissue accumulation, which can lead to the development of …

Human brown adipose tissue and metabolic health: potential for therapeutic avenues

R Singh, A Barrios, G Dirakvand, S Pervin - Cells, 2021 - mdpi.com
Obesity-associated metabolic abnormalities comprise a cluster of conditions including
dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected …

MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapies

M Panda, E Kalita, S Singh, K Kumar, A Rao… - Life Sciences, 2022 - Elsevier
COVID-19 is a highly transmissible disease caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), affects 226 countries and continents, and has resulted in> 6.2 …

Metabolic dysfunction and immunometabolism in COVID-19 pathophysiology and therapeutics

R Batabyal, N Freishtat, E Hill, M Rehman… - International Journal of …, 2021 - nature.com
The COVID-19 pandemic has emerged as a public health crisis and has placed a significant
burden on healthcare systems. Patients with underlying metabolic dysfunction, such as type …