Bioactive compounds of natural origin are gaining increasing popularity. High biological
activity and bioavailability, beneficial effects on health and safety of use are some of their …

In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30%
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …

Mitochondria are fascinating structures of the cellular compartments that generate energy to
run the cells. However, inherent disorders of mitochondria due to diabetes can cause major …

Oxidative stress (OS) is primarily caused by the formation of free radicals and reactive
oxygen species; it is considered as one of the prominent factors in slowing down and …

The prevalence of diabetes mellitus is rising all over the world. Uncontrolled state of
hyperglycemia due to defects in insulin secretion/action leads to a variety of complications …

Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin
resistance and insulin secretion impairment. These disorders, if not intervened, will …

Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction. There are three
main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress …

Diets are currently characterized by elevated sugar intake, mainly due to the increased
consumption of processed sweetened foods and drinks during the last 40 years. Diet is the …

Reactive oxygen species are generated as a by-product of routine biochemical reactions.
However, dysfunction of the antioxidant system or mutations in gene function may result in …

Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of
diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the …