The brain continuously adapts its processing machinery to behavioural demands. To
achieve this, it rapidly modulates the operating mode of cortical circuits, controlling the way …

Switches between different behavioral states of the animal are associated with prominent
changes in global brain activity, between sleep and wakefulness or from inattentive to …

The neural correlates of optimal states for signal detection task performance are largely
unknown. One hypothesis holds that optimal states exhibit tonically depolarized cortical …

Humans and most animals can learn new tasks without forgetting old ones. However,
training artificial neural networks (ANNs) on new tasks typically causes them to forget …

Sensory regions of the brain integrate environmental cues with copies of motor-related
signals important for imminent and ongoing movements. In mammals, signals propagating …

Oxytocin promotes social interactions and recognition of conspecifics that rely on olfaction in
most species. The circuit mechanisms through which oxytocin modifies olfactory processing …

Studies of visual processing in rodents have conventionally been performed on
anesthetized animals, precluding examination of the effects of behavior on visually evoked …

Currently there is no general approach for achieving specific optogenetic control of
genetically defined cell types in rats, which provide a powerful experimental system for …

Cortical sensory processing is modulated by behavioral and cognitive states. How this
modulation is achieved by changing synaptic circuits remains largely unknown. In awake …

Neocortical activity can evoke sensory percepts, but the cellular mechanisms remain poorly
understood. We trained mice to detect single brief whisker stimuli and report perceived …