Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …

Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

Integrins are the adhesion molecules and transmembrane receptors that consist of α and β
subunits. After binding to extracellular matrix components, integrins trigger intracellular …

Integrins are the adhesion molecules and receptors of extracellular matrix (ECM). They
mediate the interactions between cells-cells and cells-ECM. The crosstalk between cancer …

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays
crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain …

Integrins are a large family of transmembrane adhesion receptors, which play a key role in
interactions of a cell with the surrounding stroma. Integrins are comprised of non-covalently …

Early invasive growth along specific anatomical structures, especially the white matter tract,
is regarded as one of the main causes of poor therapeutic outcome of people with gliomas …