MicroRNA in cardiovascular biology and disease.

A Wojciechowska, A Braniewska… - … in Clinical & …, 2017 - search.ebscohost.com
MicroRNAs (miRNAs) are members of a non-coding RNA family. They act as negative
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …

The two faces of miR-29

A Slusarz, L Pulakat - Journal of cardiovascular medicine, 2015 - journals.lww.com
Diabetes mellitus is a metabolic homeostasis disease that contributes to additional
comorbidities such as cardiovascular disease (CVD) and cancer. It has a long undiagnosed …

Maternal exosomes in diabetes contribute to the cardiac development deficiency

R Shi, L Zhao, W Cai, M Wei, X Zhou, G Yang… - … and biophysical research …, 2017 - Elsevier
Maternal diabetes mellitus induces an increased risk of congenital heart defects (CHD),
however, the exact mechanisms are still not fully illustrated. In this study, diabetic pregnant …

The role of microRNAs in cardiac development and regenerative capacity

MG Katz, AS Fargnoli, AP Kendle… - American Journal …, 2016 - journals.physiology.org
The mammalian heart has long been considered to be a postmitotic organ. It was thought
that, in the postnatal period, the heart underwent a transition from hyperplasic growth (more …

The crucial role and regulations of miRNAs in zebrafish development

M Bhattacharya, AR Sharma, G Sharma, BC Patra… - Protoplasma, 2017 - Springer
To comprehend the events during developmental biology, fundamental knowledge about
the basic machinery of regulation is a prerequisite. MicroRNA (miRNAs) act as regulators in …

miR‐21 Reduces Hydrogen Peroxide‐Induced Apoptosis in c‐kit+ Cardiac Stem Cells In Vitro through PTEN/PI3K/Akt Signaling

W Deng, Y Wang, X Long, R Zhao… - Oxidative medicine …, 2016 - Wiley Online Library
The low survival rate of cardiac stem cells (CSCs) in the infarcted myocardium hampers cell
therapy for ischemic cardiomyopathy. MicroRNA‐21 (miR‐21) and one of its target proteins …

[HTML][HTML] Pathological microRNAs in acute cardiovascular diseases and microRNA therapeutics

SS Ali, C Kala, M Abid, N Ahmad, US Sharma… - Journal of Acute …, 2016 - Elsevier
Cardiovascular diseases are one of the leading causes of morbidity and mortality. In recent
researches, it is demonstrated that microRNAs (miRNAs) are expressed extensively in …

miR-21 increases c-kit+ cardiac stem cell proliferation in vitro through PTEN/PI3K/Akt signaling

B Shi, W Deng, X Long, R Zhao, Y Wang, W Chen… - PeerJ, 2017 - peerj.com
The low survival rate of cardiac stem cells (CSCs) in the ischemic myocardium is one of the
obstacles in ischemic cardiomyopathy cell therapy. The MicroRNA (miR)-21 and one of its …

Possible muscle repair in the human cardiovascular system

L Sommese, A Zullo, C Schiano, FP Mancini… - Stem Cell Reviews and …, 2017 - Springer
The regenerative potential of tissues and organs could promote survival, extended lifespan
and healthy life in multicellular organisms. Niches of adult stemness are widely distributed …

MiR218 modulates Wnt signaling in mouse cardiac stem cells by promoting proliferation and inhibiting differentiation through a positive feedback loop

Y Wang, J Liu, J Cui, M Sun, W Du, T Chen, X Ming… - Scientific Reports, 2016 - nature.com
MiRNA expression was determined in both proliferating and differentiated cardiac stem cells
(CSCs) through a comprehensive miRNA microarray analysis. We selected miR218 for …