A new generation of imids as treatments for neuroinflammatory and neurodegenerative disorders
KO Kopp, ME Greer, EJ Glotfelty, SC Hsueh… - Biomolecules, 2023 - mdpi.com
The immunomodulatory imide drug (IMiD) class, which includes the founding drug member
thalidomide and later generation drugs, lenalidomide and pomalidomide, has dramatically …
thalidomide and later generation drugs, lenalidomide and pomalidomide, has dramatically …
Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis
Eleven novel benzoxazole/benzothiazole‐based thalidomide analogs were designed and
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
Thalidomide upper limb embryopathy–pathogenesis, past and present management and future considerations
N Vargesson, G Hooper, G Giddins… - Journal of Hand …, 2023 - journals.sagepub.com
This review article provides a comprehensive overview of thalidomide upper limb
embryopathy including updates about its pathogenesis, a historical account of the …
embryopathy including updates about its pathogenesis, a historical account of the …
Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis
Y Yan, W Huang, X Lu, X Chen, Y Shan, X Luo… - Cell Biology and …, 2024 - Springer
The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their
potential toxic effects on human health. Although more and more researches have confirmed …
potential toxic effects on human health. Although more and more researches have confirmed …
Assessment of the Teratogenic Effect of Drugs on the Chicken Embryo
LR Fraga, MR de Oliveira, KM Wermann… - … Testing: Methods and …, 2024 - Springer
Pre-clinical trials are an essential step that underpins the drug discovery, development, and
safety process. During this process, animal testing is performed to determine the safety of …
safety process. During this process, animal testing is performed to determine the safety of …
[HTML][HTML] 2-(Piperidin-3-yl) phthalimides reduce classical markers of cellular inflammation in LPS-challenged RAW 264.7 cells and also demonstrate potentially …
MT Scerba, D Tweedie, NH Greig - Bioorganic & Medicinal Chemistry …, 2024 - Elsevier
Herein, we report the synthesis of new 4-amino-2-(piperidin-3-yl) isoindoline-1, 3-diones
and their biological evaluation in a series of in vitro experiments. The synthetic production of …
and their biological evaluation in a series of in vitro experiments. The synthetic production of …
Deep Learning Methods for Binding Site Prediction in Protein Structures
EP Geraseva - … (Moscow), Supplement Series B: Biomedical Chemistry, 2024 - Springer
This work is an overview of deep machine learning methods aimed at predicting binding
sites in protein structures. Several classes of methods are selected: prediction of binding …
sites in protein structures. Several classes of methods are selected: prediction of binding …
COVID-19 post vaccination neuronal adverse events: probable mechanisms and treatment possibilities
AM Baig, J Gerlach, P Salunke, R Jessey, R Rose - Future Virology, 2023 - Taylor & Francis
Early in the COVID-19 pandemic, a few cases of affected individuals with SARS-CoV-2
infection and neurological deficits were observed, but it was not until late 2020/early 2021 …
infection and neurological deficits were observed, but it was not until late 2020/early 2021 …