Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Background Alcohol use is a leading risk factor for death and disability, but its overall
association with health remains complex given the possible protective effects of moderate …

Metabolites provide a direct functional signature of cellular state. Untargeted metabolomics
experiments usually rely on tandem MS to identify the thousands of compounds in a …

ENDscript 2 is a friendly Web server for extracting and rendering a comprehensive analysis
of primary to quaternary protein structure information in an automated way. This major …

Abstract ClinVar (http://www. ncbi. nlm. nih. gov/clinvar/) provides a freely available archive
of reports of relationships among medically important variants and phenotypes. ClinVar …

Abstract DrugBank (http://www. drugbank. ca) is a comprehensive online database
containing extensive biochemical and pharmacological information about drugs, their …

Over the past decade, the Database of Genomic Variants (DGV; http://dgv. tcag. ca/) has
provided a publicly accessible, comprehensive curated catalogue of structural variation (SV) …

Motivation: The human leukocyte antigen (HLA) gene cluster plays a crucial role in adaptive
immunity and is thus relevant in many biomedical applications. While next-generation …

Abstract The National Center for Biotechnology Information (NCBI) Reference Sequence
(RefSeq) database is a collection of annotated genomic, transcript and protein sequence …

Peptidases, their substrates and inhibitors are of great relevance to biology, medicine and
biotechnology. The MEROPS database (http://merops. sanger. ac. uk) aims to fulfill the need …