Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-
spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of …

Buprenorphine, an opioid with mixed agonist-antagonist activity at classical opioid
receptors, has been approved recently for the treatment of opioid dependency …

Mu opioid receptors mediate positive reinforcement following direct (morphine) or indirect
(alcohol, cannabinoids, nicotine) activation, and our understanding of mu receptor function …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

We have investigated modulation of voltage-gated calcium channels by nociceptin (ORL1)
receptors. In rat DRG neurons and in tsA-201 cells, nociceptin mediated a pronounced …

The advance of functional genomics revealed the superfamily of G-protein coupled
receptors (GPCRs). Hundreds of GPCRs have been cloned but many of them are orphan …

Several studies show that the nociceptin receptor NOP plays a role in the regulation of
reward and motivation pathways related to substance abuse. Administration of the NOP's …

Opioids are involved in the physiological control of numerous functions of the central
nervous system, particularly nociception. It appears that some endogenous neuropeptides …