Naturalizing mouse models for immunology

AL Graham - Nature Immunology, 2021 - nature.com
Laboratory mice have provided invaluable insight into mammalian immune systems. Yet the
immune phenotypes of mice bred and maintained in conventional laboratory conditions …

Macroimmunology: The drivers and consequences of spatial patterns in wildlife immune defence

DJ Becker, GF Albery, MK Kessler… - Journal of Animal …, 2020 - Wiley Online Library
The prevalence and intensity of parasites in wild hosts varies across space and is a key
determinant of infection risk in humans, domestic animals and threatened wildlife. Because …

Land use-induced spillover: a call to action to safeguard environmental, animal, and human health

RK Plowright, JK Reaser, H Locke… - The Lancet Planetary …, 2021 - thelancet.com
The rapid global spread and human health impacts of SARS-CoV-2, the virus that causes
COVID-19, show humanity's vulnerability to zoonotic disease pandemics. Although …

Normalizing the environment recapitulates adult human immune traits in laboratory mice

LK Beura, SE Hamilton, K Bi, JM Schenkel… - Nature, 2016 - nature.com
Our current understanding of immunology was largely defined in laboratory mice, partly
because they are inbred and genetically homogeneous, can be genetically manipulated …

Interactions between multiple helminths and the gut microbiota in wild rodents

J Kreisinger, G Bastien, HC Hauffe… - … of the Royal …, 2015 - royalsocietypublishing.org
The gut microbiota is vital to host health and, as such, it is important to elucidate the
mechanisms altering its composition and diversity. Intestinal helminths are host …

Sexual dimorphism in immunity across animals: a meta‐analysis

CD Kelly, AM Stoehr, C Nunn, KN Smyth… - Ecology …, 2018 - Wiley Online Library
In animals, sex differences in immunity are proposed to shape variation in infection
prevalence and intensity among individuals in a population, with females typically expected …

The gut microbiome of laboratory mice: considerations and best practices for translational research

AC Ericsson, CL Franklin - Mammalian Genome, 2021 - Springer
Just as the gut microbiota (GM) is now recognized as an integral mediator of environmental
influences on human physiology, susceptibility to disease, and response to pharmacological …

A review of non-invasive sampling in wildlife disease and health research: what's new?

AK Schilling, MV Mazzamuto, C Romeo - Animals, 2022 - mdpi.com
Simple Summary The interest in wildlife research has increased in the last decades as more
scientists work within a One Health framework that regards human, livestock and wildlife …

The conservation physiology toolbox: status and opportunities

CL Madliger, OP Love, KR Hultine… - Conservation …, 2018 - academic.oup.com
For over a century, physiological tools and techniques have been allowing researchers to
characterize how organisms respond to changes in their natural environment and how they …

Ecophysiology meets conservation: understanding the role of disease in amphibian population declines

AR Blaustein, SS Gervasi… - … of the Royal …, 2012 - royalsocietypublishing.org
Infectious diseases are intimately associated with the dynamics of biodiversity. However, the
role that infectious disease plays within ecological communities is complex. The complex …