A bidirectional causal relationship has been established between temporomandibular
disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic …

The temporomandibular joint (TMJ) consists of bone, cartilage, ligaments, and associated
masticatory muscles and tendons that coordinate to enable mastication in mammals. The …

Itching and pain are distinct unpleasant sensations. The transient receptor potential cation
channel subfamily V member 4 (TRPV4) pathway is regarded as a shared pathway that …

Objective This study aimed to clarify the interactions between the tongue and primary
afferent fibers in tongue cancer pain. Methods A pharmacological analysis was conducted to …

There is an unmet need to identify new therapeutic targets for temporomandibular disorder
(TMD) pain because current treatments are limited and unsatisfactory. TMEM100, a two …

Identification of potential therapeutic targets is needed for temporomandibular disorders
(TMD) pain, the most common form of orofacial pain, because current treatments lack …

Background and objective Endometriosis (EM) involves the peripheral nervous system and
causes chronic pain. Sensory nerves innervating endometriotic lesions contribute to chronic …

Calcitonin gene-related peptide (CGRP) is synthesized and secreted by trigeminal ganglion
neurons, and is a key neuropeptide involved in pain and immune regulation. This study …

Nitrogen-Containing 2,3-Dihydroquinazolinone Compounds as Nav1.8 Inhibitors for
Treating Pain and Cardiovascular Diseases Page 1 Nitrogen-Containing 2,3-Dihydroquinazolinone …

Persistent corneal pain (PCP) has excellent research prospects, especially the central
sensitization mechanism of the trigeminal nerve, which is involved in migraine, corneal pain …