Engineered and total biosynthesis of fungal specialized metabolites
RJ Cox - Nature Reviews Chemistry, 2024 - nature.com
Filamentous fungi produce a very wide range of complex and often bioactive metabolites,
demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent …
demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent …
Hunting for the Intermolecular Diels–Alderase
L Gao, Q Ding, X Lei - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus The Diels–Alder reaction is well known as a concerted [4+ 2] cycloaddition
governed by the Woodward–Hoffmann rules. Since Prof. Otto Diels and his student Kurt …
governed by the Woodward–Hoffmann rules. Since Prof. Otto Diels and his student Kurt …
Investigation of N-Glycan Functions in Receptor for Advanced Glycation End Products V Domain through Chemical Glycoprotein Synthesis
W Dong, X Yang, X Li, S Wei, C An… - Journal of the …, 2024 - ACS Publications
The receptor for advanced glycation end products (RAGE) plays a crucial role in
inflammation-related pathways and various chronic diseases. Despite the recognized …
inflammation-related pathways and various chronic diseases. Despite the recognized …
Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from Angelica sinensis and Its Bioinspired Total Synthesis
J Zou, ZC Qiu, QQ Yu, JM Wu, YH Wang… - ACS Central …, 2024 - ACS Publications
Angelica sinensis, commonly known as Dong Quai in Europe and America and as Dang-gui
in China, is a medicinal plant widely utilized for the prevention and treatment of …
in China, is a medicinal plant widely utilized for the prevention and treatment of …
Phomaketals A and B, pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.
C Li, Y Han, Y Zhai, K Li, X Liu, Z Zhang, C Jia… - Chinese Chemical …, 2024 - Elsevier
Abstract Phomaketals A (1) and B (2), two tropolonic meroterpenoids with the
unprecedented pentacyclic skeletons, were isolated from the solid-substrate fermentation …
unprecedented pentacyclic skeletons, were isolated from the solid-substrate fermentation …
Catalytic domino reaction: A promising and economic tool in organic synthesis
L Bai, X Jiang - Chem Catalysis, 2023 - cell.com
Catalytic domino reactions represent preeminent advances in contemporary synthetic
organic chemistry to achieve the challenging historical goal of assembling complex …
organic chemistry to achieve the challenging historical goal of assembling complex …
ADME Study, Molecular Docking, Elucidating the Selectivities and the Mechanism of [4 + 2] Cycloaddition Reaction Between (E)-N ((dimethylamino)methylene) …
M Atif, A Barhoumi, A Syed, AH Bahkali, M Chafi… - Molecular …, 2024 - Springer
The molecular electron density theory (MEDT) was employed to examine the [4+ 2]
cycloaddition reaction between (E)-N-((dimethylamino) methylene) benzothioamide (1) and …
cycloaddition reaction between (E)-N-((dimethylamino) methylene) benzothioamide (1) and …
Biosynthesis and Assembly Logic of Fungal Hybrid Terpenoid Natural Products
GY Yuan, JM Zhang, YQ Xu, Y Zou - ChemBioChem, 2024 - Wiley Online Library
In recent decades, fungi have emerged as significant sources of diverse hybrid terpenoid
natural products, and their biosynthetic pathways are increasingly unveiled. This review …
natural products, and their biosynthetic pathways are increasingly unveiled. This review …
Editing function of type II thioesterases in the biosynthesis of fungal polyketides
F Jiang, A Liu, Q Wei, Y Hu - Chinese Chemical Letters, 2024 - Elsevier
Polyketide synthases (PKSs) are megasynthases with multiple autonomously folding
domains, which operate cooperatively in the PKS assemblies to synthesize specific …
domains, which operate cooperatively in the PKS assemblies to synthesize specific …