[HTML][HTML] The ubiquitin proteasome system—implications for cell cycle control and the targeted treatment of cancer
Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the
timely and precise ubiquitin–proteasome-dependent degradation of key cell cycle proteins …
timely and precise ubiquitin–proteasome-dependent degradation of key cell cycle proteins …
Panta rhei: the APC/C at steady state
I Primorac, A Musacchio - Journal of Cell Biology, 2013 - rupress.org
The anaphase-promoting complex or cyclosome (APC/C) is a conserved, multisubunit E3
ubiquitin (Ub) ligase that is active both in dividing and in postmitotic cells. Its contributions to …
ubiquitin (Ub) ligase that is active both in dividing and in postmitotic cells. Its contributions to …
Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells
We have found that key mitotic regulators show distinct patterns of degradation during exit
from mitosis in human cells. Using a live-cell assay for proteolysis, we show that two of these …
from mitosis in human cells. Using a live-cell assay for proteolysis, we show that two of these …
Mitosis: a matter of getting rid of the right protein at the right time
J Pines - Trends in cell biology, 2006 - cell.com
There are two major problems for the cell to solve in mitosis: how to ensure that each
daughter cell receives an equal and identical complement of the genome, and how to …
daughter cell receives an equal and identical complement of the genome, and how to …
A roller coaster ride with the mitotic cyclins
Cyclins are discovered as proteins that accumulate progressively through interphase and
disappear abruptly at mitosis during each cell cycle. In mammalian cells, cyclin A …
disappear abruptly at mitosis during each cell cycle. In mammalian cells, cyclin A …
Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome–Cdh1-mediated pathway
PY Ke, ZF Chang - Molecular and cellular biology, 2004 - Taylor & Francis
The expression of human thymidine kinase 1 (hTK1) is highly dependent on the growth
states and cell cycle stages in mammalian cells. The amount of hTK1 is significantly …
states and cell cycle stages in mammalian cells. The amount of hTK1 is significantly …
Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
The temporal control of mitotic protein degradation remains incompletely understood. In
particular, it is unclear why the mitotic checkpoint prevents the anaphase-promoting …
particular, it is unclear why the mitotic checkpoint prevents the anaphase-promoting …
[PDF][PDF] Oocyte maturation: a story of arrest and release
A Sen, F Caiazza - Front Biosci (Schol Ed), 2013 - researchgate.net
[Frontiers in Bioscience S5, 451-477, January 1, 2013] Oocyte Maturation: A story of arrest and
release Aritro Sen1, Francesco C Page 1 [Frontiers in Bioscience S5, 451-477, January 1 …
release Aritro Sen1, Francesco C Page 1 [Frontiers in Bioscience S5, 451-477, January 1 …
Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase
The forkhead box M1 (FoxM1) transcription factor is overexpressed in many cancers, and in
mouse models it is required for tumor progression. FoxM1 activates expression of the cell …
mouse models it is required for tumor progression. FoxM1 activates expression of the cell …
Structure, function and mechanism of the anaphase promoting complex (APC/C)
D Barford - Quarterly reviews of biophysics, 2011 - cambridge.org
The complex molecular events responsible for coordinating chromosome replication and
segregation with cell division and growth are collectively known as the cell cycle …
segregation with cell division and growth are collectively known as the cell cycle …